57201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 581083..581560 Replicon chromosome
Accession NZ_CP012756
Organism Staphylococcus aureus strain JS395

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ACH32_RS03120 Protein ID WP_000052076.1
Coordinates 581372..581560 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ACH32_RS03115 Protein ID WP_001059690.1
Coordinates 581083..581343 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACH32_RS03080 576476..577192 - 717 WP_000150034.1 type I 3-dehydroquinate dehydratase -
ACH32_RS03085 577340..577762 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
ACH32_RS03090 578161..578655 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ACH32_RS03095 578811..579428 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
ACH32_RS03100 579501..580082 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
ACH32_RS03105 580306..580542 + 237 WP_000368687.1 hypothetical protein -
ACH32_RS03110 580539..580742 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
ACH32_RS03115 581083..581343 + 261 WP_001059690.1 hypothetical protein Antitoxin
ACH32_RS03120 581372..581560 + 189 WP_000052076.1 hypothetical protein Toxin
ACH32_RS03125 581748..582317 + 570 WP_001106662.1 hypothetical protein -
ACH32_RS03130 582405..582689 + 285 WP_001004401.1 hypothetical protein -
ACH32_RS03135 582751..582969 + 219 WP_000005884.1 hypothetical protein -
ACH32_RS03140 583494..583694 - 201 WP_001059082.1 cold-shock protein -
ACH32_RS03145 584057..584725 - 669 WP_000141442.1 thermonuclease family protein -
ACH32_RS03150 585067..585537 - 471 WP_000824466.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T57201 WP_000052076.1 NZ_CP012756:581372-581560 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T57201 NZ_CP012756:581372-581560 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGTTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGTAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT57201 WP_001059690.1 NZ_CP012756:581083-581343 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT57201 NZ_CP012756:581083-581343 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References