Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 34730..35481 Replicon plasmid KP-p1
Accession NZ_CP012754
Organism Klebsiella pneumoniae strain KP617

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag AN966_RS26810 Protein ID WP_014386536.1
Coordinates 34999..35481 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag AN966_RS26805 Protein ID WP_004902250.1
Coordinates 34730..35008 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN966_RS30965 30373..30798 - 426 WP_000522996.1 organomercurial transporter MerC -
AN966_RS30970 30826..31101 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
AN966_RS29825 31117..31482 - 366 WP_004200999.1 mercuric ion transporter MerT -
AN966_RS26780 31554..32009 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
AN966_RS26785 32662..33120 + 459 WP_014386535.1 hypothetical protein -
AN966_RS26795 33950..34291 + 342 WP_004902257.1 hypothetical protein -
AN966_RS26800 34399..34611 + 213 WP_004902255.1 hypothetical protein -
AN966_RS26805 34730..35008 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
AN966_RS26810 34999..35481 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
AN966_RS26820 36516..37055 + 540 WP_004902239.1 hypothetical protein -
AN966_RS26825 37160..37552 + 393 WP_032442757.1 hypothetical protein -
AN966_RS26830 37653..38408 + 756 WP_004902235.1 DUF2971 domain-containing protein -
AN966_RS26835 38435..39082 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VI / blaNDM-1 / qnrB1 / dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) - 1..273628 273628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T57193 WP_014386536.1 NZ_CP012754:34999-35481 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T57193 NZ_CP012754:34999-35481 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT57193 WP_004902250.1 NZ_CP012754:34730-35008 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT57193 NZ_CP012754:34730-35008 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References