Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3090837..3091353 Replicon chromosome
Accession NZ_CP012753
Organism Klebsiella pneumoniae strain KP617

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag AN966_RS15180 Protein ID WP_004178374.1
Coordinates 3090837..3091121 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AN966_RS15185 Protein ID WP_002886901.1
Coordinates 3091111..3091353 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN966_RS15150 3086321..3086629 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
AN966_RS30580 3086714..3086887 + 174 WP_032408826.1 hypothetical protein -
AN966_RS15160 3086890..3087633 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AN966_RS15170 3087990..3090128 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AN966_RS15175 3090369..3090833 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AN966_RS15180 3090837..3091121 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN966_RS15185 3091111..3091353 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AN966_RS15190 3091431..3093341 - 1911 WP_004178373.1 BglG family transcription antiterminator -
AN966_RS15195 3093364..3094518 - 1155 WP_004178372.1 lactonase family protein -
AN966_RS15200 3094585..3095325 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T57188 WP_004178374.1 NZ_CP012753:c3091121-3090837 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T57188 NZ_CP012753:c3091121-3090837 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT57188 WP_002886901.1 NZ_CP012753:c3091353-3091111 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT57188 NZ_CP012753:c3091353-3091111 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References