Detailed information of TA system TA057175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 9984440..9985026
• Replicon: chromosome
• Accession: NZ_CP012752
• Organism: Kibdelosporangium phytohabitans strain KLBMP1111

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: AOZ06_RS55430
• Protein ID: WP_083472343.1
• Coordinates: 9984682..9985026 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A0N9IAA0
• Locus tag: AOZ06_RS44550
• Protein ID: WP_054294885.1
• Coordinates: 9984440..9984688 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOZ06_RS44525	9980953..9981441	+	489	WP_054294880.1	carbonic anhydrase	-
AOZ06_RS44530	9981438..9981791	-	354	WP_054294881.1	arsenate reductase family protein	-
AOZ06_RS44535	9981810..9982511	+	702	WP_054294882.1	protein phosphatase 2C domain-containing protein	-
AOZ06_RS44540	9982495..9983193	-	699	WP_054294883.1	peptidylprolyl isomerase	-
AOZ06_RS44545	9983288..9984394	+	1107	WP_054294884.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
AOZ06_RS44550	9984440..9984688	+	249	WP_054294885.1	ribbon-helix-helix domain-containing protein	Antitoxin
AOZ06_RS55430	9984682..9985026	+	345	WP_083472343.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AOZ06_RS44555	9985030..9985335	-	306	WP_157233588.1	hypothetical protein	-
AOZ06_RS44560	9985626..9986066	-	441	WP_054294887.1	MarR family transcriptional regulator	-
AOZ06_RS44565	9986198..9987220	+	1023	WP_083472870.1	substrate-binding domain-containing protein	-
AOZ06_RS44570	9987309..9987566	+	258	WP_054294889.1	amphi-Trp domain-containing protein	-
AOZ06_RS44575	9987605..9988981	-	1377	WP_083472871.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 11950.72 Da
• Isoelectric Point: 8.7387

>T57175 WP_083472343.1 NZ_CP012752:9984682-9985026 [Kibdelosporangium phytohabitans]
VVIERGNIHWADLGEADGSRPAKRRPVLVIQANPYNASRLATVLAAVLTSNTILATAPGNVFLPASATGLPRDSVVNVTA
LVTLNKDDLSGQVGEVPISLMRDVDSGLRRALAL

Nucleotide

• Length: 345 bp

>T57175 NZ_CP012752:9984682-9985026 [Kibdelosporangium phytohabitans]
GTGGTGATCGAACGCGGCAACATCCACTGGGCGGATCTGGGTGAGGCCGACGGCTCACGTCCAGCAAAACGCCGCCCGGT
ACTTGTCATTCAAGCAAATCCCTACAACGCGAGTCGACTCGCGACAGTGCTCGCGGCGGTTCTCACCTCCAACACGATAT
TGGCCACTGCGCCGGGAAACGTTTTCCTGCCCGCGTCCGCCACAGGACTGCCGCGAGATTCGGTGGTGAACGTGACCGCA
CTGGTCACCCTGAACAAGGACGACCTGTCCGGGCAGGTGGGAGAAGTTCCCATCAGTCTGATGCGCGACGTTGACTCGGG
GCTACGTCGAGCGCTCGCACTATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8828.55 Da
• Isoelectric Point: 4.3176

>AT57175 WP_054294885.1 NZ_CP012752:9984440-9984688 [Kibdelosporangium phytohabitans]
VKTAISVPDETFAQVDRSAKSLGVTRSEFYARAARFYLEHLEQESLTNEINDALDVIGSADDSGTAAAAAGRHRVAGSDD
EW

Nucleotide

• Length: 249 bp

>AT57175 NZ_CP012752:9984440-9984688 [Kibdelosporangium phytohabitans]
GTGAAGACAGCGATCTCAGTACCCGATGAGACGTTCGCCCAGGTGGATCGAAGCGCCAAGTCTCTGGGCGTGACCCGCTC
GGAGTTCTACGCGCGCGCGGCCCGCTTCTACTTGGAGCACCTCGAGCAGGAGTCTTTGACCAACGAGATCAATGACGCCC
TCGACGTCATCGGCAGTGCGGATGACTCCGGCACCGCCGCTGCCGCGGCCGGTCGGCACCGCGTGGCGGGATCAGACGAC
GAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0N9IAA0