Detailed information of TA system TA057173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 797440..798095
• Replicon: chromosome
• Accession: NZ_CP012750
• Organism: Glutamicibacter halophytocola strain KLBMP 5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AOZ07_RS03780
• Protein ID: WP_060700780.1
• Coordinates: 797670..798095 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AOZ07_RS03775
• Protein ID: WP_060700779.1
• Coordinates: 797440..797673 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOZ07_RS03760	792628..793977	-	1350	WP_098945535.1	DHA2 family efflux MFS transporter permease subunit	-
AOZ07_RS03765	794241..794840	+	600	WP_194943785.1	TetR family transcriptional regulator	-
AOZ07_RS03770	795060..797282	+	2223	WP_060700778.1	NADP-dependent isocitrate dehydrogenase	-
AOZ07_RS03775	797440..797673	+	234	WP_060700779.1	Arc family DNA-binding protein	Antitoxin
AOZ07_RS03780	797670..798095	+	426	WP_060700780.1	type II toxin-antitoxin system VapC family toxin	Toxin
AOZ07_RS03785	798369..799631	-	1263	WP_194943786.1	hypothetical protein	-
AOZ07_RS18675	799788..799925	+	138	WP_194943854.1	NADP-dependent isocitrate dehydrogenase	-
AOZ07_RS18680	800226..801050	+	825	WP_194943787.1	Abi family protein	-
AOZ07_RS03790	801305..802837	-	1533	WP_060700782.1	dNTP triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	791208..847044	55836

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

• Arc-like DNA binding domain (12-41)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14856.91 Da
• Isoelectric Point: 4.8836

>T57173 WP_060700780.1 NZ_CP012750:797670-798095 [Glutamicibacter halophytocola]
VIVLDTNVLSEIFRPSPETHVVEWLASLTGDVAITSVTLAELLSGVRKLPDGRRKTALAKSIESVLGQYRGSRSVLPFDE
AAAECYAVVLAAREGAGAPISTADAQIAAICLAHDATCATRNTKDFEHTGIDLINPWIAGG

Nucleotide

• Length: 426 bp

>T57173 NZ_CP012750:797670-798095 [Glutamicibacter halophytocola]
GTGATAGTCCTCGACACGAATGTCCTCTCAGAGATCTTCCGGCCCTCGCCGGAGACTCACGTCGTCGAGTGGCTCGCGTC
GCTGACGGGGGACGTTGCCATCACATCGGTGACGCTCGCCGAGCTGCTCTCTGGGGTGAGGAAGCTGCCGGACGGCCGCC
GAAAGACAGCGCTGGCGAAGAGCATCGAATCGGTGCTCGGACAGTACCGGGGAAGTCGATCGGTCCTGCCGTTCGATGAA
GCGGCGGCGGAATGCTACGCGGTCGTACTGGCAGCCCGCGAGGGCGCCGGAGCGCCGATCAGCACGGCCGATGCTCAGAT
TGCCGCGATTTGCCTGGCGCATGACGCGACGTGCGCGACGCGCAACACCAAGGACTTCGAACACACCGGCATTGACCTGA
TTAATCCGTGGATAGCTGGCGGGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8178.36 Da
• Isoelectric Point: 5.7905

>AT57173 WP_060700779.1 NZ_CP012750:797440-797673 [Glutamicibacter halophytocola]
MPSIIVRGLDDAVKQQLAAQAKEHGRSMEAEVRDILTKAARRPNIGMALLAAAQEAGGVQELPVPGRDDIARSVDFG

Nucleotide

• Length: 234 bp

>AT57173 NZ_CP012750:797440-797673 [Glutamicibacter halophytocola]
ATGCCATCCATCATCGTTCGCGGTCTTGACGACGCGGTGAAGCAGCAACTCGCCGCGCAGGCGAAGGAACACGGCCGGTC
CATGGAAGCCGAAGTCCGCGACATCCTCACCAAGGCAGCCAGGCGGCCGAACATCGGCATGGCCTTGCTGGCTGCGGCTC
AAGAGGCCGGCGGTGTCCAAGAACTTCCAGTTCCAGGGCGTGATGACATCGCAAGATCGGTGGACTTCGGGTGA