Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3029284..3029822 Replicon chromosome
Accession NZ_CP012747
Organism Paraburkholderia caribensis MBA4

Toxin (Protein)


Gene name parE Uniprot ID A0A0P0RJY6
Locus tag K788_RS28950 Protein ID WP_035996951.1
Coordinates 3029523..3029822 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7Z7BL02
Locus tag K788_RS28945 Protein ID WP_007738653.1
Coordinates 3029284..3029526 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K788_RS28925 3025081..3027601 + 2521 Protein_2641 DNA ligase D -
K788_RS28930 3028063..3028410 - 348 WP_057176753.1 hypothetical protein -
K788_RS28935 3028543..3028863 - 321 WP_035996954.1 CcdB family protein -
K788_RS28940 3028863..3029129 - 267 WP_079495511.1 type II toxin-antitoxin system CcdA family antitoxin -
K788_RS28945 3029284..3029526 + 243 WP_007738653.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K788_RS28950 3029523..3029822 + 300 WP_035996951.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K788_RS28955 3030640..3030927 + 288 WP_035996948.1 hypothetical protein -
K788_RS28960 3031033..3032100 + 1068 WP_035996945.1 cytochrome c oxidase subunit II -
K788_RS28965 3032097..3034694 + 2598 WP_035996942.1 cytochrome c oxidase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11342.75 Da        Isoelectric Point: 5.0911

>T57171 WP_035996951.1 NZ_CP012747:3029523-3029822 [Paraburkholderia caribensis MBA4]
VKECVLSPAAELDLDDIWDYSAENWGIRQAERYIRMIQDTIVGLTDETQPSQAASHVRPDYRSALVGTHILFFKETDNLI
DVIRILHQRMDPSKHPSGH

Download         Length: 300 bp

>T57171 NZ_CP012747:3029523-3029822 [Paraburkholderia caribensis MBA4]
GTGAAGGAATGTGTTCTCTCGCCAGCGGCCGAGCTGGATCTCGATGATATCTGGGACTATTCGGCGGAAAACTGGGGGAT
ACGGCAGGCGGAGCGTTATATCCGCATGATCCAGGACACGATCGTTGGATTGACTGATGAAACACAGCCGAGTCAGGCCG
CCTCCCACGTTCGGCCTGACTACCGCAGTGCGCTGGTCGGAACTCACATTCTGTTTTTCAAAGAAACCGACAACCTTATC
GACGTTATCCGGATTCTTCATCAGCGGATGGATCCTTCCAAACACCCGAGCGGGCACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8970.06 Da        Isoelectric Point: 8.6582

>AT57171 WP_007738653.1 NZ_CP012747:3029284-3029526 [Paraburkholderia caribensis MBA4]
MGKNTSVSLGDHFAEFVEDRVRAGRYNTASDVVRAGLRLLEEQEAKLDALRVELEKGERSGPSRPFDFDAFLARKRKSAT

Download         Length: 243 bp

>AT57171 NZ_CP012747:3029284-3029526 [Paraburkholderia caribensis MBA4]
ATGGGCAAGAACACATCCGTTTCGCTCGGCGACCACTTCGCCGAATTTGTCGAAGATCGCGTGCGCGCCGGGCGCTACAA
CACGGCGAGCGACGTGGTTCGAGCTGGCCTGCGTTTGCTGGAGGAACAGGAAGCAAAACTCGATGCTTTGCGCGTCGAGC
TGGAGAAGGGCGAGCGCTCGGGCCCATCCAGGCCGTTTGACTTTGACGCGTTTCTCGCACGCAAGAGGAAGTCCGCGACG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0RJY6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7BL02

References