Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1961349..1963099 Replicon chromosome
Accession NZ_CP012747
Organism Paraburkholderia caribensis MBA4

Toxin (Protein)


Gene name doc Uniprot ID A0A0P0RH85
Locus tag K788_RS24360 Protein ID WP_035999010.1
Coordinates 1962206..1963099 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag K788_RS24355 Protein ID WP_036001997.1
Coordinates 1961349..1962209 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K788_RS24335 1956545..1958041 - 1497 WP_035999021.1 aldehyde dehydrogenase -
K788_RS24340 1958069..1958899 - 831 WP_035999019.1 aspartate dehydrogenase -
K788_RS24345 1958892..1960550 - 1659 WP_035999016.1 thiamine pyrophosphate-binding protein -
K788_RS24350 1960543..1961349 - 807 WP_035999012.1 SDR family oxidoreductase -
K788_RS24355 1961349..1962209 - 861 WP_036001997.1 IclR family transcriptional regulator Antitoxin
K788_RS24360 1962206..1963099 - 894 WP_035999010.1 alpha/beta fold hydrolase Toxin
K788_RS24365 1963131..1963670 - 540 WP_035999007.1 cupin domain-containing protein -
K788_RS24370 1963706..1964464 - 759 WP_035999005.1 SDR family oxidoreductase -
K788_RS24375 1964457..1965545 - 1089 WP_035999003.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
K788_RS24380 1965588..1965899 - 312 WP_035999001.1 hypothetical protein -
K788_RS24385 1965901..1966218 - 318 WP_035998998.1 non-heme iron oxygenase ferredoxin subunit -
K788_RS24390 1966659..1967732 + 1074 WP_035998994.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-275)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 30953.94 Da        Isoelectric Point: 6.7507

>T57170 WP_035999010.1 NZ_CP012747:c1963099-1962206 [Paraburkholderia caribensis MBA4]
MPAALPVTADRNATLETRLSHFPAQRIAIALQRAIGYREAGAAHADALPLVLLHGIGSGAASWVQQLEALSATRRVFAWD
APGYGESTPVASASPKADEYAGALDAWLDALAVDRCVLVGHSLGAIIAGSFAASRAQRVAGLLLISPAAGYGAASEAVRA
SKRDSRLALLAELGPQGLADQRSANMLSQRADEASRDWVRWNMSRIVPTGYAQATHLLANADLASDVAGINGPIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAANEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T57170 NZ_CP012747:c1963099-1962206 [Paraburkholderia caribensis MBA4]
ATGCCCGCAGCCTTGCCCGTCACTGCCGATCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCGTAT
CGCGATTGCGCTGCAACGCGCGATCGGCTATCGCGAAGCGGGTGCCGCGCATGCCGATGCGTTACCACTCGTGCTGTTGC
ACGGCATCGGCTCGGGCGCGGCTTCGTGGGTGCAACAACTCGAAGCGTTGAGTGCGACGCGCCGCGTGTTCGCGTGGGAC
GCACCGGGCTATGGCGAATCGACGCCCGTTGCGTCGGCTTCGCCCAAAGCAGATGAATACGCTGGCGCGCTCGACGCATG
GCTCGACGCACTCGCCGTAGACCGTTGCGTACTGGTCGGGCATTCACTCGGCGCGATCATCGCGGGCTCGTTCGCGGCGT
CGCGTGCGCAACGCGTCGCGGGGTTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCGCGGCATCCGAAGCAGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGCTGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCAGCGCGCCGATGAAGCATCGCGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCAGGGATCAACGGCCCTATCGCCGTCGCGGTCGGGGCG
GAAGACTCGATCACACCGCCGTCGTCATGCGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAACGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31409.82 Da        Isoelectric Point: 6.5089

>AT57170 WP_036001997.1 NZ_CP012747:c1962209-1961349 [Paraburkholderia caribensis MBA4]
MTPELTGTAPEAEDDRNDASYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDDLRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRGAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT57170 NZ_CP012747:c1962209-1961349 [Paraburkholderia caribensis MBA4]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTTTCACCGCGCGAGCCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACACTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTTGGCTTCGAATATCTCAGTTCACTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGTTTGCGCGACGCGACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGTTGCCCGCGCATGCGACCACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGACCTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGCTTCGCGATCAGCGAATCGT
CGTTTGAAAACGGTATTTCGGTGATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACGACGACG
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0RH85

Antitoxin

Source ID Structure

References