Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1961349..1963099 Replicon chromosome
Accession NZ_CP012747
Organism Paraburkholderia caribensis MBA4

Toxin (Protein)


Gene name doc Uniprot ID A0A0P0RH85
Locus tag K788_RS24360 Protein ID WP_035999010.1
Coordinates 1962206..1963099 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag K788_RS24355 Protein ID WP_036001997.1
Coordinates 1961349..1962209 (-) Length 287 a.a.

Genomic Context

K788_RS24390K788_RS24335K788_RS24340K788_RS24345K788_RS24350K788_RS24355K788_RS24360K788_RS24365K788_RS24370K788_RS24375K788_RS24380K788_RS24385
Location: 1966659..1967732 (1074 bp)
Type: Others
Protein ID: WP_035998994.1
Location: 1956545..1958041 (1497 bp)
Type: Others
Protein ID: WP_035999021.1
Location: 1958069..1958899 (831 bp)
Type: Others
Protein ID: WP_035999019.1
Location: 1958892..1960550 (1659 bp)
Type: Others
Protein ID: WP_035999016.1
Location: 1960543..1961349 (807 bp)
Type: Others
Protein ID: WP_035999012.1
Location: 1961349..1962209 (861 bp)
Type: Antitoxin
Protein ID: WP_036001997.1
Location: 1962206..1963099 (894 bp)
Type: Toxin
Protein ID: WP_035999010.1
Location: 1963131..1963670 (540 bp)
Type: Others
Protein ID: WP_035999007.1
Location: 1963706..1964464 (759 bp)
Type: Others
Protein ID: WP_035999005.1
Location: 1964457..1965545 (1089 bp)
Type: Others
Protein ID: WP_035999003.1
Location: 1965588..1965899 (312 bp)
Type: Others
Protein ID: WP_035999001.1
Location: 1965901..1966218 (318 bp)
Type: Others
Protein ID: WP_035998998.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K788_RS243351956545..1958041-1497WP_035999021.1aldehyde dehydrogenase-
K788_RS243401958069..1958899-831WP_035999019.1aspartate dehydrogenase-
K788_RS243451958892..1960550-1659WP_035999016.1thiamine pyrophosphate-binding protein-
K788_RS243501960543..1961349-807WP_035999012.1SDR family oxidoreductase-
K788_RS243551961349..1962209-861WP_036001997.1IclR family transcriptional regulatorAntitoxin
K788_RS243601962206..1963099-894WP_035999010.1alpha/beta fold hydrolaseToxin
K788_RS243651963131..1963670-540WP_035999007.1cupin domain-containing protein-
K788_RS243701963706..1964464-759WP_035999005.1SDR family oxidoreductase-
K788_RS243751964457..1965545-1089WP_035999003.1aromatic ring-hydroxylating dioxygenase subunit alpha-
K788_RS243801965588..1965899-312WP_035999001.1hypothetical protein-
K788_RS243851965901..1966218-318WP_035998998.1non-heme iron oxygenase ferredoxin subunit-
K788_RS243901966659..1967732+1074WP_035998994.1porin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-275)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 30953.94 Da        Isoelectric Point: 6.7507

>T57170 WP_035999010.1 NZ_CP012747:c1963099-1962206 [Paraburkholderia caribensis MBA4]
MPAALPVTADRNATLETRLSHFPAQRIAIALQRAIGYREAGAAHADALPLVLLHGIGSGAASWVQQLEALSATRRVFAWD
APGYGESTPVASASPKADEYAGALDAWLDALAVDRCVLVGHSLGAIIAGSFAASRAQRVAGLLLISPAAGYGAASEAVRA
SKRDSRLALLAELGPQGLADQRSANMLSQRADEASRDWVRWNMSRIVPTGYAQATHLLANADLASDVAGINGPIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAANEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T57170 NZ_CP012747:c1963099-1962206 [Paraburkholderia caribensis MBA4]
ATGCCCGCAGCCTTGCCCGTCACTGCCGATCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCGTAT
CGCGATTGCGCTGCAACGCGCGATCGGCTATCGCGAAGCGGGTGCCGCGCATGCCGATGCGTTACCACTCGTGCTGTTGC
ACGGCATCGGCTCGGGCGCGGCTTCGTGGGTGCAACAACTCGAAGCGTTGAGTGCGACGCGCCGCGTGTTCGCGTGGGAC
GCACCGGGCTATGGCGAATCGACGCCCGTTGCGTCGGCTTCGCCCAAAGCAGATGAATACGCTGGCGCGCTCGACGCATG
GCTCGACGCACTCGCCGTAGACCGTTGCGTACTGGTCGGGCATTCACTCGGCGCGATCATCGCGGGCTCGTTCGCGGCGT
CGCGTGCGCAACGCGTCGCGGGGTTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCGCGGCATCCGAAGCAGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGCTGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCAGCGCGCCGATGAAGCATCGCGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCAGGGATCAACGGCCCTATCGCCGTCGCGGTCGGGGCG
GAAGACTCGATCACACCGCCGTCGTCATGCGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAACGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31409.82 Da        Isoelectric Point: 6.5089

>AT57170 WP_036001997.1 NZ_CP012747:c1962209-1961349 [Paraburkholderia caribensis MBA4]
MTPELTGTAPEAEDDRNDASYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDDLRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRGAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT57170 NZ_CP012747:c1962209-1961349 [Paraburkholderia caribensis MBA4]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTTTCACCGCGCGAGCCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACACTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTTGGCTTCGAATATCTCAGTTCACTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGTTTGCGCGACGCGACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGTTGCCCGCGCATGCGACCACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGACCTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGCTTCGCGATCAGCGAATCGT
CGTTTGAAAACGGTATTTCGGTGATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACGACGACG
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0P0RH85

Antitoxin

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Source
ID
Structure
No matching records found

References