Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 2768209..2768869 Replicon chromosome
Accession NZ_CP012746
Organism Paraburkholderia caribensis MBA4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K788_RS12305 Protein ID WP_082624873.1
Coordinates 2768209..2768637 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K788_RS12310 Protein ID WP_035991398.1
Coordinates 2768624..2768869 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K788_RS12285 2764260..2765216 - 957 WP_035991011.1 sugar ABC transporter substrate-binding protein -
K788_RS12290 2765772..2766410 + 639 WP_035991009.1 LysE family translocator -
K788_RS12295 2766453..2767430 - 978 WP_035991007.1 magnesium/cobalt transporter CorA -
K788_RS12300 2767635..2768108 - 474 WP_082624872.1 hypothetical protein -
K788_RS12305 2768209..2768637 - 429 WP_082624873.1 type II toxin-antitoxin system VapC family toxin Toxin
K788_RS12310 2768624..2768869 - 246 WP_035991398.1 DNA-binding protein Antitoxin
K788_RS12315 2769038..2769658 + 621 WP_035991001.1 ATP-binding protein -
K788_RS12320 2769814..2770911 - 1098 WP_035990998.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
K788_RS12325 2771119..2771583 - 465 WP_035990996.1 Lrp/AsnC family transcriptional regulator -
K788_RS12330 2771720..2772604 - 885 WP_035990994.1 LysR family transcriptional regulator -
K788_RS12335 2772758..2773270 + 513 WP_035990992.1 Spy/CpxP family protein refolding chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15657.83 Da        Isoelectric Point: 7.4682

>T57169 WP_082624873.1 NZ_CP012746:c2768637-2768209 [Paraburkholderia caribensis MBA4]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSHI
LNVGTDVAQTWGHLRVPDAGHALDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLPDA

Download         Length: 429 bp

>T57169 NZ_CP012746:c2768637-2768209 [Paraburkholderia caribensis MBA4]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCGGGCGTACAGGCTTTTTTCGA
AACGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCCGTCGTGACGGTCGGCGAGCTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCGTTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCAGCAGCCACATC
CTGAATGTCGGCACCGACGTCGCGCAGACGTGGGGCCATCTGCGCGTGCCCGACGCCGGGCACGCGCTGGACAAACTGAT
CGCGGCCACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TCAATCCGTTCCAGCTTCCTGACGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8938.90 Da        Isoelectric Point: 4.2208

>AT57169 WP_035991398.1 NZ_CP012746:c2768869-2768624 [Paraburkholderia caribensis MBA4]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPRKLSFAELLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT57169 NZ_CP012746:c2768869-2768624 [Paraburkholderia caribensis MBA4]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATTCTGGCGCAGGCGCTTTTTCAGCCCAGGAAGCTCAGCTTCGCGGAGTTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGCAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References