Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4808480..4808996 Replicon chromosome
Accession NZ_CP012744
Organism Klebsiella pneumoniae subsp. pneumoniae strain TGH10

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AOG31_RS24115 Protein ID WP_002886902.1
Coordinates 4808480..4808764 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AOG31_RS24120 Protein ID WP_002886901.1
Coordinates 4808754..4808996 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOG31_RS24085 4803896..4804204 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
AOG31_RS30495 4804289..4804462 + 174 WP_032408826.1 hypothetical protein -
AOG31_RS24095 4804465..4805208 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AOG31_RS24105 4805565..4807703 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AOG31_RS24110 4808012..4808476 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AOG31_RS24115 4808480..4808764 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOG31_RS24120 4808754..4808996 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AOG31_RS24125 4809074..4810984 - 1911 WP_062921034.1 BglG family transcription antiterminator -
AOG31_RS24130 4811007..4812161 - 1155 WP_002886900.1 lactonase family protein -
AOG31_RS24135 4812228..4812968 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T57148 WP_002886902.1 NZ_CP012744:c4808764-4808480 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T57148 NZ_CP012744:c4808764-4808480 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT57148 WP_002886901.1 NZ_CP012744:c4808996-4808754 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT57148 NZ_CP012744:c4808996-4808754 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References