Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 938355..939012 Replicon chromosome
Accession NZ_CP012743
Organism Klebsiella pneumoniae subsp. pneumoniae strain TGH8

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AOD72_RS04730 Protein ID WP_002916310.1
Coordinates 938602..939012 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AOD72_RS04725 Protein ID WP_002916312.1
Coordinates 938355..938621 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOD72_RS04700 933511..934944 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
AOD72_RS04705 935063..935791 - 729 WP_062920457.1 MurR/RpiR family transcriptional regulator -
AOD72_RS04710 935841..936152 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AOD72_RS04715 936316..936975 + 660 WP_002916317.1 hemolysin III family protein -
AOD72_RS04720 937126..938109 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AOD72_RS04725 938355..938621 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AOD72_RS04730 938602..939012 + 411 WP_002916310.1 protein YgfX Toxin
AOD72_RS04735 939019..939540 - 522 WP_004144730.1 flavodoxin FldB -
AOD72_RS04740 939641..940537 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AOD72_RS04745 940560..941273 + 714 WP_062920458.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AOD72_RS04750 941279..943012 + 1734 WP_062920459.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T57119 WP_002916310.1 NZ_CP012743:938602-939012 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T57119 NZ_CP012743:938602-939012 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCTCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT57119 WP_002916312.1 NZ_CP012743:938355-938621 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57119 NZ_CP012743:938355-938621 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References