Detailed information of TA system TA057115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 355865..356424
• Replicon: chromosome
• Accession: NZ_CP012740
• Organism: Vibrio vulnificus strain FORC_017

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC17_RS16615
• Protein ID: WP_047111817.1
• Coordinates: 356146..356424 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: FORC17_RS16610
• Protein ID: WP_011082348.1
• Coordinates: 355865..356149 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC17_RS16580	351010..352203	+	1194	WP_011082341.1	glycine C-acetyltransferase	-
FORC17_RS16585	352240..353265	+	1026	WP_197672410.1	L-threonine 3-dehydrogenase	-
FORC17_RS16590	353345..353845	-	501	WP_065090958.1	hypothetical protein	-
FORC17_RS16595	353923..354186	-	264	WP_011082346.1	hypothetical protein	-
FORC17_RS16600	354371..354904	-	534	WP_065090959.1	hypothetical protein	-
FORC17_RS16605	355039..355647	-	609	WP_011151714.1	hypothetical protein	-
FORC17_RS16610	355865..356149	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC17_RS16615	356146..356424	+	279	WP_047111817.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FORC17_RS25415	356453..356512	-	60	WP_081280400.1	DUF3265 domain-containing protein	-
FORC17_RS16620	356572..358356	-	1785	WP_065090960.1	NACHT domain-containing protein	-
FORC17_RS24545	358401..358502	-	102	WP_081280401.1	DUF3265 domain-containing protein	-
FORC17_RS16625	358520..359080	-	561	WP_065090961.1	hypothetical protein	-
FORC17_RS16630	360135..360650	-	516	WP_065090962.1	lipocalin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	355039..359080	4041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10951.63 Da
• Isoelectric Point: 4.3430

>T57115 WP_047111817.1 NZ_CP012740:356146-356424 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIETKVENLLEQPLMGVQRDSIRGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T57115 NZ_CP012740:356146-356424 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAACAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCGCGGTCGATTACTCATTATTCCCGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT57115 WP_011082348.1 NZ_CP012740:355865-356149 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT57115 NZ_CP012740:355865-356149 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCAGAGAGTCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGGGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2