57114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2609471..2611299 Replicon chromosome
Accession NZ_CP012739
Organism Vibrio vulnificus strain FORC_017

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC17_RS12105 Protein ID WP_043877077.1
Coordinates 2609471..2610832 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC17_RS12110 Protein ID WP_029786578.1
Coordinates 2610817..2611299 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC17_RS12075 2604890..2606554 + 1665 WP_045595834.1 DNA repair protein RecN -
FORC17_RS12080 2606733..2607092 + 360 WP_011078463.1 outer membrane protein assembly factor BamE -
FORC17_RS12085 2607203..2607556 - 354 WP_011078464.1 RnfH family protein -
FORC17_RS12090 2607553..2607984 - 432 WP_026050324.1 ubiquinone-binding protein -
FORC17_RS12095 2608100..2608585 + 486 WP_011078466.1 SsrA-binding protein SmpB -
FORC17_RS12105 2609471..2610832 + 1362 WP_043877077.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC17_RS12110 2610817..2611299 + 483 WP_029786578.1 helix-turn-helix domain-containing protein Antitoxin
FORC17_RS12115 2611737..2613479 - 1743 WP_011078501.1 lysophospholipid acyltransferase family protein -
FORC17_RS12120 2613522..2613959 - 438 WP_011078502.1 YHS domain-containing protein -
FORC17_RS12125 2613974..2614729 - 756 WP_065090694.1 NRDE family protein -
FORC17_RS12130 2614731..2615285 - 555 WP_011078504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51446.22 Da        Isoelectric Point: 4.8137

>T57114 WP_043877077.1 NZ_CP012739:2609471-2610832 [Vibrio vulnificus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFNDMGKPGWLKFLDDIM
PSGASRRYWVRYLDIEDLSSDEQDYVLLKFGTMSPVGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYALQRGAAA
GGATGAGGEAPKLILRCGLDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEITASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T57114 NZ_CP012739:2609471-2610832 [Vibrio vulnificus]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAAGTGAATGGATAGACATTGGTATCATCTCATTCCCAAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTAATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGCGGCGCTAGTAGACGGTACTGGGTCAGATATCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTGTTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACTGCAAAGGGGCGCAGCCGCG
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTCTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCAGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTAATGAGCA
GCAAATCGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCATTAGAGGTTGGCGGAACTTACGACTTCATCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAGGTGTTATTACAAGAGCTAGAGATTACTGCAAGTAAATGCATTGACTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT57114 WP_029786578.1 NZ_CP012739:2610817-2611299 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT57114 NZ_CP012739:2610817-2611299 [Vibrio vulnificus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCGGATATAGAGAATGATCGGGGAAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AGCCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References