Detailed information of TA system TA057113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1570182..1570698
• Replicon: chromosome
• Accession: NZ_CP012739
• Organism: Vibrio vulnificus strain FORC_017

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FORC17_RS07380
• Protein ID: WP_005492798.1
• Coordinates: 1570429..1570698 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FORC17_RS07375
• Protein ID: WP_005492799.1
• Coordinates: 1570182..1570436 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC17_RS24185	1565636..1565725	+	90	WP_196229925.1	DUF3265 domain-containing protein	-
FORC17_RS07340	1565735..1566214	+	480	WP_025580509.1	hypothetical protein	-
FORC17_RS24190	1566211..1566333	+	123	WP_081280333.1	DUF3265 domain-containing protein	-
FORC17_RS07345	1566470..1567021	+	552	WP_065090399.1	hypothetical protein	-
FORC17_RS07350	1567177..1567650	+	474	WP_045620645.1	GNAT family N-acetyltransferase	-
FORC17_RS24195	1567626..1567769	+	144	WP_081280334.1	DUF3265 domain-containing protein	-
FORC17_RS07355	1567794..1568267	+	474	WP_061058585.1	hypothetical protein	-
FORC17_RS24200	1568292..1568399	+	108	WP_081280335.1	DUF3265 domain-containing protein	-
FORC17_RS07360	1568410..1568865	+	456	WP_173652400.1	GNAT family N-acetyltransferase	-
FORC17_RS07365	1569037..1569327	+	291	WP_047109842.1	hypothetical protein	-
FORC17_RS07370	1569499..1569963	+	465	WP_065090401.1	ASCH domain-containing protein	-
FORC17_RS24210	1569968..1570090	+	123	WP_081280336.1	DUF3265 domain-containing protein	-
FORC17_RS07375	1570182..1570436	+	255	WP_005492799.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FORC17_RS07380	1570429..1570698	+	270	WP_005492798.1	Txe/YoeB family addiction module toxin	Toxin
FORC17_RS24215	1570700..1570849	+	150	WP_145923193.1	DUF3265 domain-containing protein	-
FORC17_RS24220	1571183..1571344	+	162	WP_081280260.1	DUF3265 domain-containing protein	-
FORC17_RS07385	1571304..1571759	+	456	WP_065090402.1	GNAT family N-acetyltransferase	-
FORC17_RS07390	1572485..1572937	+	453	WP_045620640.1	hypothetical protein	-
FORC17_RS24230	1572934..1573056	+	123	Protein_1521	DUF3265 domain-containing protein	-
FORC17_RS07395	1573234..1573494	+	261	WP_043877387.1	DUF4282 domain-containing protein	-
FORC17_RS24235	1573481..1573675	+	195	WP_081280338.1	DUF3265 domain-containing protein	-
FORC17_RS07400	1573651..1573965	+	315	WP_065090403.1	DUF4144 domain-containing protein	-
FORC17_RS24240	1574009..1574128	+	120	WP_081280261.1	DUF3265 domain-containing protein	-
FORC17_RS07405	1574115..1574444	+	330	WP_065090404.1	hypothetical protein	-
FORC17_RS07410	1574578..1574952	+	375	WP_065090405.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1433137..1608704	175567
	-	inside	Integron	-	-	1431925..1601873	169948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10557.95 Da
• Isoelectric Point: 8.8578

>T57113 WP_005492798.1 NZ_CP012739:1570429-1570698 [Vibrio vulnificus]
MSSSQRLLSWTDDAWSDYLYWQTQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAL
TIISCRYHY

Nucleotide

• Length: 270 bp

>T57113 NZ_CP012739:1570429-1570698 [Vibrio vulnificus]
ATGAGTAGTAGTCAACGTTTACTATCTTGGACTGACGATGCTTGGAGTGATTATTTGTACTGGCAAACCCAAGACAAGAA
AACTTTAAAACGAATCAATAAGCTAATTACTGACGTTAAACGTTCTCCTTTTGAGGGCATAGGTAAACCAGAGCCATTAA
AAGAAAACCTAGCTGGTTTTTGGTCACGCCGTATTGATGACACTAATAGACTTGTCTATGCCGTTGATGATCAGGCACTC
ACGATAATTTCGTGTCGCTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9498.68 Da
• Isoelectric Point: 5.1007

>AT57113 WP_005492799.1 NZ_CP012739:1570182-1570436 [Vibrio vulnificus]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLKRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT57113 NZ_CP012739:1570182-1570436 [Vibrio vulnificus]
ATGAGAATCGTATCTTTTACAGAAGCTAGAAATAGTCTCAAAGCGGTTTTAGATGGTGTCGTCAATGATGCAGACACAAC
CGTTATTACTCGTCGTGATTCGGAAGATGCAGTGGTTATGTCCCTAGACTATTACAATAGTCTTATGGAGACCGTTCATT
TACTTCGCTCTCCTGAAAATGCTGAGCATTTAAAACGTTCGATAGCCCAGTATCGTGCTGGTAAAACTACAGCACGAGAA
TTAATCGATGAGTAG