57112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1563282..1563829 Replicon chromosome
Accession NZ_CP012739
Organism Vibrio vulnificus strain FORC_017

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag FORC17_RS07320 Protein ID WP_025548916.1
Coordinates 1563527..1563829 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag FORC17_RS07315 Protein ID WP_005448240.1
Coordinates 1563282..1563539 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC17_RS24160 1558850..1558942 + 93 WP_079863845.1 DUF3265 domain-containing protein -
FORC17_RS24990 1560010..1560666 + 657 WP_065090394.1 hypothetical protein -
FORC17_RS24995 1560684..1560772 + 89 Protein_1492 DUF3265 domain-containing protein -
FORC17_RS07300 1560800..1561483 + 684 WP_065090395.1 hypothetical protein -
FORC17_RS07305 1561605..1562060 + 456 WP_065090396.1 hypothetical protein -
FORC17_RS24175 1562530..1562652 + 123 WP_080262734.1 DUF3265 domain-containing protein -
FORC17_RS07310 1562672..1563079 + 408 WP_011150339.1 NUDIX hydrolase -
FORC17_RS24180 1563086..1563211 + 126 WP_072612497.1 DUF3265 domain-containing protein -
FORC17_RS07315 1563282..1563539 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC17_RS07320 1563527..1563829 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC17_RS07325 1563992..1564387 + 396 WP_065090397.1 ACT domain-containing protein -
FORC17_RS07330 1564542..1564988 + 447 WP_065090398.1 GNAT family N-acetyltransferase -
FORC17_RS07335 1565142..1565618 + 477 WP_038512113.1 GNAT family N-acetyltransferase -
FORC17_RS24185 1565636..1565725 + 90 WP_196229925.1 DUF3265 domain-containing protein -
FORC17_RS07340 1565735..1566214 + 480 WP_025580509.1 hypothetical protein -
FORC17_RS24190 1566211..1566333 + 123 WP_081280333.1 DUF3265 domain-containing protein -
FORC17_RS07345 1566470..1567021 + 552 WP_065090399.1 hypothetical protein -
FORC17_RS07350 1567177..1567650 + 474 WP_045620645.1 GNAT family N-acetyltransferase -
FORC17_RS24195 1567626..1567769 + 144 WP_081280334.1 DUF3265 domain-containing protein -
FORC17_RS07355 1567794..1568267 + 474 WP_061058585.1 hypothetical protein -
FORC17_RS24200 1568292..1568399 + 108 WP_081280335.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1433137..1608704 175567
- inside Integron - - 1431925..1601873 169948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T57112 WP_025548916.1 NZ_CP012739:1563527-1563829 [Vibrio vulnificus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T57112 NZ_CP012739:1563527-1563829 [Vibrio vulnificus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT57112 WP_005448240.1 NZ_CP012739:1563282-1563539 [Vibrio vulnificus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT57112 NZ_CP012739:1563282-1563539 [Vibrio vulnificus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAACCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References