Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1475878..1476416 | Replicon | chromosome |
| Accession | NZ_CP012739 | ||
| Organism | Vibrio vulnificus strain FORC_017 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A3Q0L5T8 |
| Locus tag | FORC17_RS06790 | Protein ID | WP_001247271.1 |
| Coordinates | 1475878..1476177 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | FORC17_RS06795 | Protein ID | WP_065090346.1 |
| Coordinates | 1476174..1476416 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC17_RS06755 | 1471623..1472051 | + | 429 | WP_065090344.1 | GNAT family N-acetyltransferase | - |
| FORC17_RS06760 | 1472173..1472508 | + | 336 | WP_043920982.1 | hypothetical protein | - |
| FORC17_RS06765 | 1472680..1473489 | + | 810 | WP_011080280.1 | hypothetical protein | - |
| FORC17_RS23690 | 1473494..1473667 | + | 174 | WP_081280313.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06770 | 1473633..1473983 | + | 351 | WP_061058614.1 | hypothetical protein | - |
| FORC17_RS06775 | 1474137..1474631 | + | 495 | WP_065090345.1 | GNAT family N-acetyltransferase | - |
| FORC17_RS06780 | 1474773..1475294 | + | 522 | WP_053317388.1 | hypothetical protein | - |
| FORC17_RS06785 | 1475519..1475737 | + | 219 | WP_021453865.1 | hypothetical protein | - |
| FORC17_RS23695 | 1475759..1475944 | + | 186 | WP_081280225.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06790 | 1475878..1476177 | - | 300 | WP_001247271.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC17_RS06795 | 1476174..1476416 | - | 243 | WP_065090346.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FORC17_RS24845 | 1476502..1476609 | + | 108 | WP_128824624.1 | DUF3265 domain-containing protein | - |
| FORC17_RS24850 | 1476975..1477076 | + | 102 | WP_145923179.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06800 | 1477101..1477580 | + | 480 | WP_065090347.1 | GNAT family N-acetyltransferase | - |
| FORC17_RS06805 | 1478154..1478840 | + | 687 | WP_045624033.1 | hypothetical protein | - |
| FORC17_RS23705 | 1479444..1479575 | + | 132 | WP_080768274.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06810 | 1479602..1480051 | + | 450 | WP_065090348.1 | GNAT family N-acetyltransferase | - |
| FORC17_RS24860 | 1480092..1480169 | + | 78 | WP_072606006.1 | hypothetical protein | - |
| FORC17_RS06815 | 1480196..1480489 | + | 294 | WP_065090349.1 | hypothetical protein | - |
| FORC17_RS23710 | 1480514..1480624 | + | 111 | WP_080553514.1 | DUF3265 domain-containing protein | - |
| FORC17_RS23720 | 1480985..1481107 | + | 123 | Protein_1322 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1433137..1608704 | 175567 | |
| - | flank | IS/Tn | - | - | 1470413..1471189 | 776 | |
| - | inside | Integron | - | - | 1431925..1601873 | 169948 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11703.39 Da Isoelectric Point: 9.9572
>T57111 WP_001247271.1 NZ_CP012739:c1476177-1475878 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
Download Length: 300 bp
>T57111 NZ_CP012739:c1476177-1475878 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8967.90 Da Isoelectric Point: 4.2213
>AT57111 WP_065090346.1 NZ_CP012739:c1476416-1476174 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLLEGEESGVADYDLDSFINELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLLEGEESGVADYDLDSFINELDSEERK
Download Length: 243 bp
>AT57111 NZ_CP012739:c1476416-1476174 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
ATCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTCTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
ATCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTCTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|