Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1446941..1447506 | Replicon | chromosome |
| Accession | NZ_CP012739 | ||
| Organism | Vibrio vulnificus strain FORC_017 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FORC17_RS06600 | Protein ID | WP_065090329.1 |
| Coordinates | 1447219..1447506 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | FORC17_RS06595 | Protein ID | WP_000086649.1 |
| Coordinates | 1446941..1447222 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC17_RS06565 | 1441991..1442671 | + | 681 | WP_001898508.1 | DUF4145 domain-containing protein | - |
| FORC17_RS23550 | 1442853..1443176 | + | 324 | WP_081280211.1 | DUF3709 domain-containing protein | - |
| FORC17_RS06570 | 1443450..1443968 | + | 519 | WP_065090325.1 | GNAT family N-acetyltransferase | - |
| FORC17_RS06575 | 1444264..1444446 | + | 183 | WP_065090326.1 | DUF645 family protein | - |
| FORC17_RS06580 | 1444645..1445280 | + | 636 | WP_000691786.1 | DUF2807 domain-containing protein | - |
| FORC17_RS06590 | 1445691..1446680 | - | 990 | WP_158513826.1 | Fic family protein | - |
| FORC17_RS06595 | 1446941..1447222 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC17_RS06600 | 1447219..1447506 | + | 288 | WP_065090329.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC17_RS06605 | 1447668..1448141 | + | 474 | WP_065090330.1 | hypothetical protein | - |
| FORC17_RS23555 | 1448159..1448266 | + | 108 | WP_081280308.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06610 | 1448274..1448705 | + | 432 | WP_065090331.1 | DUF2513 domain-containing protein | - |
| FORC17_RS25395 | 1449009..1449137 | + | 129 | WP_000947521.1 | DUF645 family protein | - |
| FORC17_RS25400 | 1449153..1449191 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| FORC17_RS06620 | 1449389..1450171 | + | 783 | WP_065090332.1 | hypothetical protein | - |
| FORC17_RS23565 | 1450161..1450283 | + | 123 | WP_197672403.1 | DUF3265 domain-containing protein | - |
| FORC17_RS06625 | 1450335..1450655 | + | 321 | WP_052298473.1 | hypothetical protein | - |
| FORC17_RS23570 | 1450690..1450844 | + | 155 | Protein_1257 | DUF3265 domain-containing protein | - |
| FORC17_RS06630 | 1450882..1451214 | + | 333 | WP_012600340.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC17_RS06635 | 1451201..1451515 | + | 315 | WP_017049537.1 | DNA-binding transcriptional regulator | - |
| FORC17_RS23575 | 1451530..1451622 | + | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| FORC17_RS23580 | 1451984..1452106 | + | 123 | WP_072611569.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1433137..1608704 | 175567 | |
| - | inside | Integron | - | - | 1431925..1601873 | 169948 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11017.73 Da Isoelectric Point: 6.0710
>T57109 WP_065090329.1 NZ_CP012739:1447219-1447506 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFIALDNPSGAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSGAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T57109 NZ_CP012739:1447219-1447506 [Vibrio vulnificus]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTAGATAACCCATCAGG
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTTAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTAGATAACCCATCAGG
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTTAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT57109 WP_000086649.1 NZ_CP012739:1446941-1447222 [Vibrio vulnificus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT57109 NZ_CP012739:1446941-1447222 [Vibrio vulnificus]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|