Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3381221..3382016 | Replicon | chromosome |
| Accession | NZ_CP012735 | ||
| Organism | Shigella flexneri 1a strain 0228 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | AOT98_RS18445 | Protein ID | WP_000854917.1 |
| Coordinates | 3381642..3382016 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | AOT98_RS18440 | Protein ID | WP_001280958.1 |
| Coordinates | 3381221..3381595 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOT98_RS18400 (3376635) | 3376635..3377021 | + | 387 | Protein_3251 | AraC family transcriptional regulator | - |
| AOT98_RS18405 (3377110) | 3377110..3377807 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| AOT98_RS30345 (3377990) | 3377990..3378253 | + | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| AOT98_RS29310 (3378373) | 3378373..3378546 | + | 174 | WP_000088744.1 | DUF905 family protein | - |
| AOT98_RS18415 (3378646) | 3378646..3379467 | + | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| AOT98_RS29320 (3379809) | 3379809..3380282 | + | 474 | WP_005011597.1 | antirestriction protein | - |
| AOT98_RS18425 (3380298) | 3380298..3380774 | + | 477 | WP_005011624.1 | RadC family protein | - |
| AOT98_RS18430 (3380837) | 3380837..3381058 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| AOT98_RS18440 (3381221) | 3381221..3381595 | + | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AOT98_RS18445 (3381642) | 3381642..3382016 | + | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| AOT98_RS18450 (3382013) | 3382013..3382504 | + | 492 | WP_000976828.1 | DUF5983 family protein | - |
| AOT98_RS18455 (3382516) | 3382516..3382713 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| AOT98_RS18460 (3382798) | 3382798..3383358 | + | 561 | Protein_3263 | DUF4942 domain-containing protein | - |
| AOT98_RS18465 (3383430) | 3383430..3384434 | + | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| AOT98_RS18470 (3384716) | 3384716..3384997 | + | 282 | Protein_3265 | DUF4942 domain-containing protein | - |
| AOT98_RS18480 (3385469) | 3385469..3386407 | + | 939 | Protein_3266 | glyoxylate/hydroxypyruvate reductase GhrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / catA1 / blaOXA-1 / ant(3'')-Ia | csgG / csgF / csgE / csgD / csgB | 3337731..3391930 | 54199 | |
| - | flank | IS/Tn | - | - | 3383430..3384434 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T57093 WP_000854917.1 NZ_CP012735:3381642-3382016 [Shigella flexneri 1a]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T57093 NZ_CP012735:3381642-3382016 [Shigella flexneri 1a]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT57093 WP_001280958.1 NZ_CP012735:3381221-3381595 [Shigella flexneri 1a]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT57093 NZ_CP012735:3381221-3381595 [Shigella flexneri 1a]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |