Detailed information of TA system TA057084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 2012430..2013567
• Replicon: chromosome
• Accession: NZ_CP012731
• Organism: Streptococcus suis strain 90-1330

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: AN924_RS10085
• Protein ID: WP_079764356.1
• Coordinates: 2012430..2013293 (-)
• Length: 288 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: AN924_RS10090
• Protein ID: WP_000301765.1
• Coordinates: 2013295..2013567 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN924_RS10040	2007540..2008013	-	474	WP_062897132.1	phage terminase small subunit P27 family	-
AN924_RS10045	2008073..2008363	-	291	WP_044693299.1	hypothetical protein	-
AN924_RS10050	2008347..2008745	-	399	WP_062897133.1	hypothetical protein	-
AN924_RS10055	2008727..2010070	-	1344	WP_062897134.1	hypothetical protein	-
AN924_RS10060	2010070..2010459	-	390	WP_062897135.1	hypothetical protein	-
AN924_RS10065	2010566..2010931	-	366	WP_062897136.1	HNH endonuclease	-
AN924_RS10070	2010956..2011327	-	372	WP_062897137.1	hypothetical protein	-
AN924_RS10075	2011360..2011887	-	528	Protein_1927	methionine adenosyltransferase domain-containing protein	-
AN924_RS10080	2011889..2012348	+	460	Protein_1928	IS3 family transposase	-
AN924_RS10085	2012430..2013293	-	864	WP_079764356.1	zeta toxin family protein	Toxin
AN924_RS10090	2013295..2013567	-	273	WP_000301765.1	antitoxin	Antitoxin
AN924_RS10095	2013584..2013793	-	210	WP_000527317.1	peptide-binding protein	-
AN924_RS10100	2013891..2014787	-	897	WP_001809760.1	ParA family protein	-
AN924_RS11120	2014890..2015174	-	285	WP_073459356.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
AN924_RS10105	2015320..2016057	-	738	WP_001038796.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
AN924_RS10110	2016182..2016277	-	96	WP_062897138.1	23S rRNA methyltransferase attenuation leader peptide	-
AN924_RS10115	2016298..2016462	-	165	WP_002935077.1	peptide-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	erm(B)	-	1995895..2019349	23454
	-	inside	IS/Tn	erm(B) / tet(O)	-	2012130..2021889	9759

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-214)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 288 a.a.
• Molecular weight: 32396.95 Da
• Isoelectric Point: 6.6610

>T57084 WP_079764356.1 NZ_CP012731:c2013293-2012430 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRLAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL

Nucleotide

• Length: 864 bp

>T57084 NZ_CP012731:c2013293-2012430 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATTAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT57084 WP_000301765.1 NZ_CP012731:c2013567-2013295 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT57084 NZ_CP012731:c2013567-2013295 [Streptococcus suis]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829F0A3