Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 2003250..2004364 Replicon chromosome
Accession NZ_CP012731
Organism Streptococcus suis strain 90-1330

Toxin (Protein)


Gene name pezA Uniprot ID -
Locus tag AN924_RS10000 Protein ID WP_062897127.1
Coordinates 2003250..2003888 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag AN924_RS10005 Protein ID WP_062897128.1
Coordinates 2003888..2004364 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN924_RS09985 1999030..2001066 - 2037 WP_000456196.1 ATP-binding protein -
AN924_RS09990 2001069..2002247 - 1179 WP_001121910.1 DNA cytosine methyltransferase -
AN924_RS09995 2002336..2003175 - 840 Protein_1911 IS982 family transposase -
AN924_RS10000 2003250..2003888 - 639 WP_062897127.1 zeta toxin family protein Toxin
AN924_RS10005 2003888..2004364 - 477 WP_062897128.1 helix-turn-helix domain-containing protein Antitoxin
AN924_RS10010 2004434..2004724 - 291 WP_014636613.1 hypothetical protein -
AN924_RS10015 2004774..2005163 - 390 WP_062897129.1 hypothetical protein -
AN924_RS10020 2005160..2005387 - 228 WP_000110922.1 hypothetical protein -
AN924_RS10025 2005441..2006517 - 1077 WP_062897130.1 toprim domain-containing protein -
AN924_RS10030 2006557..2007195 - 639 WP_043037122.1 hypothetical protein -
AN924_RS10035 2007295..2007543 - 249 Protein_1919 terminase large subunit -
AN924_RS10040 2007540..2008013 - 474 WP_062897132.1 phage terminase small subunit P27 family -
AN924_RS10045 2008073..2008363 - 291 WP_044693299.1 hypothetical protein -
AN924_RS10050 2008347..2008745 - 399 WP_062897133.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage erm(B) - 1995895..2019349 23454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(30-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 24137.47 Da        Isoelectric Point: 8.6706

>T57083 WP_062897127.1 NZ_CP012731:c2003888-2003250 [Streptococcus suis]
MRLEEFSEATFQKALQRTVRALTRGKTILGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLRSKGYQVSLAVIGTKPELSYLSPLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTYPWC

Download         Length: 639 bp

>T57083 NZ_CP012731:c2003888-2003250 [Streptococcus suis]
ATGAGACTGGAAGAATTCAGTGAGGCTACATTTCAGAAGGCCTTGCAACGAACCGTTCGGGCCTTAACCCGAGGAAAGAC
GATTCTAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGGGCAGGTAAGACAACGATACATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGTGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGAACTTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTACTCCGTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAGCTTTCTTATCTCAGCCCTTTGATTCGTTACGAAGAG
CTTTATGCTATAGATCCGACCCAGGCCAGAGCAACACCCAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTCGAAAGCGATAAACTCTTTGACCAGATTCAGATTTATCAAAGAGATAGAACTTACCCGTGGTGCTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18264.76 Da        Isoelectric Point: 4.5446

>AT57083 WP_062897128.1 NZ_CP012731:c2004364-2003888 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSIELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQAIAFDDESNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT57083 NZ_CP012731:c2004364-2003888 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAATAGAACTCATCGATCGTATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAGCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGCTATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGATACTTTCGATG
AGATTGAGCGTTATAATGGCTACTTAGACGGTATCGAACGGATGCTAGACATGGTACATCATCGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References