Detailed information of TA system TA057082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1919008..1919494
• Replicon: chromosome
• Accession: NZ_CP012731
• Organism: Streptococcus suis strain 90-1330

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AN924_RS09635
• Protein ID: WP_062897123.1
• Coordinates: 1919008..1919265 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0K2E5B0
• Locus tag: AN924_RS09640
• Protein ID: WP_002935014.1
• Coordinates: 1919255..1919494 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN924_RS09615	1914639..1915709	+	1071	WP_002935006.1	tyrosine recombinase XerS	-
AN924_RS09620	1915779..1917287	-	1509	WP_062897121.1	phosphoglucomutase	-
AN924_RS09625	1917364..1918305	-	942	WP_053864590.1	sensor histidine kinase	-
AN924_RS09630	1918302..1918967	-	666	WP_062897122.1	response regulator transcription factor	-
AN924_RS09635	1919008..1919265	-	258	WP_062897123.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AN924_RS09640	1919255..1919494	-	240	WP_002935014.1	hypothetical protein	Antitoxin
AN924_RS09645	1919586..1921556	-	1971	WP_013730363.1	FtsX-like permease family protein	-
AN924_RS09650	1921557..1922309	-	753	WP_002935019.1	ABC transporter ATP-binding protein	-
AN924_RS09655	1922326..1922709	-	384	WP_002935021.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
AN924_RS09660	1922722..1922862	-	141	WP_002935023.1	hypothetical protein	-
AN924_RS09665	1922961..1923695	-	735	WP_002935025.1	beta-carotene 15,15'-monooxygenase	-
AN924_RS11325	1923708..1923845	-	138	WP_002935027.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-76)

Antitoxin

• Protein of unknown function DUF6290 (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9849.52 Da
• Isoelectric Point: 10.7134

>T57082 WP_062897123.1 NZ_CP012731:c1919265-1919008 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSLKM
RNGSI

Nucleotide

• Length: 258 bp

>T57082 NZ_CP012731:c1919265-1919008 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGTCTAAAAATG
AGAAATGGAAGTATATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8924.19 Da
• Isoelectric Point: 3.9191

>AT57082 WP_002935014.1 NZ_CP012731:c1919494-1919255 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT57082 NZ_CP012731:c1919494-1919255 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0K2E5B0