Detailed information of TA system TA057080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1228651..1229257
• Replicon: chromosome
• Accession: NZ_CP012731
• Organism: Streptococcus suis strain 90-1330

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AN924_RS06240
• Protein ID: WP_062897092.1
• Coordinates: 1228928..1229257 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0Z8LVV9
• Locus tag: AN924_RS06235
• Protein ID: WP_002940311.1
• Coordinates: 1228651..1228938 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN924_RS06200	1224275..1224634	+	360	WP_002940332.1	ribonuclease P protein component	-
AN924_RS06205	1224618..1225430	+	813	WP_002940331.1	YidC/Oxa1 family membrane protein insertase	-
AN924_RS06210	1225450..1226445	+	996	WP_062897089.1	protein jag	-
AN924_RS06215	1226613..1226750	+	138	WP_002939016.1	50S ribosomal protein L34	-
AN924_RS06220	1226857..1227639	+	783	WP_079764350.1	TatD family hydrolase	-
AN924_RS06225	1227602..1228192	+	591	WP_062897090.1	ribonuclease M5	-
AN924_RS06230	1228185..1228553	+	369	WP_062897091.1	hypothetical protein	-
AN924_RS06235	1228651..1228938	+	288	WP_002940311.1	hypothetical protein	Antitoxin
AN924_RS06240	1228928..1229257	+	330	WP_062897092.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AN924_RS06245	1229264..1229719	+	456	WP_029943578.1	8-oxo-dGTP diphosphatase	-
AN924_RS06250	1229795..1230055	+	261	WP_029693774.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
AN924_RS06255	1230057..1230314	+	258	WP_002940288.1	Txe/YoeB family addiction module toxin	-
AN924_RS06260	1230328..1230858	+	531	WP_062897093.1	DUF1697 domain-containing protein	-
AN924_RS06265	1230877..1231749	+	873	WP_002939007.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
AN924_RS06270	1231952..1233682	+	1731	WP_062897094.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12581.54 Da
• Isoelectric Point: 6.4768

>T57080 WP_062897092.1 NZ_CP012731:1228928-1229257 [Streptococcus suis]
MEFESYSVMLAPAVEKELAAIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T57080 NZ_CP012731:1228928-1229257 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATGCTTGCTCCAGCAGTGGAGAAGGAATTGGCAGCTATTTACGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTTGAAGCTTTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTCGAAAAAGAAGTGCGAGTTGGTCACCTTTTTGCGACCAAGAGTGATTATGTCAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10911.52 Da
• Isoelectric Point: 4.3472

>AT57080 WP_002940311.1 NZ_CP012731:1228651-1228938 [Streptococcus suis]
MITIKKDAQVNFKTDSRLLEKAKEIFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLESVKEKYGI

Nucleotide

• Length: 288 bp

>AT57080 NZ_CP012731:1228651-1228938 [Streptococcus suis]
TTGATAACTATAAAAAAAGATGCCCAAGTAAATTTTAAAACTGACTCCAGACTTTTGGAAAAAGCCAAGGAAATATTTGC
TATGAACCAGTTGGATTTGACGGCTGGTTTCAATCTCTTTTTGCAAAACATTGCTGTAAAAAATGAGTTGCCAATTCTGA
CTGAAGAGGAATTGGAAAGAGAAGAGTTATTTTTACAGCTTCAGAAGGAAATACAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8LVV9