Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 562994..563480 Replicon chromosome
Accession NZ_CP012731
Organism Streptococcus suis strain 90-1330

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag AN924_RS02740 Protein ID WP_011922754.1
Coordinates 562994..563263 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag AN924_RS02745 Protein ID WP_002938604.1
Coordinates 563253..563480 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN924_RS02720 558828..559802 - 975 WP_002937257.1 YvcK family protein -
AN924_RS02725 559799..560686 - 888 WP_002937261.1 RNase adapter RapZ -
AN924_RS02730 560708..561085 - 378 WP_013730303.1 RidA family protein -
AN924_RS02735 561269..562588 - 1320 WP_002937278.1 MATE family efflux transporter -
AN924_RS02740 562994..563263 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN924_RS02745 563253..563480 - 228 WP_002938604.1 hypothetical protein Antitoxin
AN924_RS02750 563752..565098 - 1347 WP_013730302.1 asparagine--tRNA ligase -
AN924_RS02755 565113..566294 - 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
AN924_RS02760 566291..566788 - 498 WP_002938611.1 DUF5590 domain-containing protein -
AN924_RS02765 567091..567540 + 450 WP_009909619.1 MarR family transcriptional regulator -
AN924_RS02770 567603..568148 + 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T57079 WP_011922754.1 NZ_CP012731:c563263-562994 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T57079 NZ_CP012731:c563263-562994 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT57079 WP_002938604.1 NZ_CP012731:c563480-563253 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT57079 NZ_CP012731:c563480-563253 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References