Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 239848..240522 | Replicon | chromosome |
| Accession | NZ_CP012731 | ||
| Organism | Streptococcus suis strain 90-1330 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A123U128 |
| Locus tag | AN924_RS01170 | Protein ID | WP_009910449.1 |
| Coordinates | 240340..240522 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A7Y6VEQ2 |
| Locus tag | AN924_RS01165 | Protein ID | WP_009910448.1 |
| Coordinates | 239848..240300 (-) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AN924_RS01135 | 235843..236847 | + | 1005 | WP_009910438.1 | lactonase family protein | - |
| AN924_RS01140 | 236911..237096 | + | 186 | WP_002935693.1 | hypothetical protein | - |
| AN924_RS01145 | 237129..237770 | - | 642 | WP_062897072.1 | HAD family hydrolase | - |
| AN924_RS01150 | 237937..238197 | - | 261 | WP_009910443.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AN924_RS01155 | 238199..238420 | - | 222 | WP_012775256.1 | hypothetical protein | - |
| AN924_RS01160 | 239527..239736 | - | 210 | WP_009910447.1 | hypothetical protein | - |
| AN924_RS01165 | 239848..240300 | - | 453 | WP_009910448.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| AN924_RS01170 | 240340..240522 | - | 183 | WP_009910449.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| AN924_RS01175 | 240706..241092 | - | 387 | WP_009910450.1 | hypothetical protein | - |
| AN924_RS01180 | 241232..241732 | - | 501 | WP_024409209.1 | hypothetical protein | - |
| AN924_RS01185 | 241802..242242 | - | 441 | WP_024409208.1 | hypothetical protein | - |
| AN924_RS01190 | 242710..243555 | - | 846 | WP_024409207.1 | ATP-binding protein | - |
| AN924_RS01195 | 243571..244365 | - | 795 | WP_079269917.1 | DnaD domain protein | - |
| AN924_RS01200 | 244379..244594 | - | 216 | WP_024409205.1 | hypothetical protein | - |
| AN924_RS11275 | 244599..244757 | - | 159 | WP_162841287.1 | hypothetical protein | - |
| AN924_RS01205 | 244768..245034 | - | 267 | WP_024409204.1 | hypothetical protein | - |
| AN924_RS01210 | 245045..245248 | - | 204 | WP_024409203.1 | hypothetical protein | - |
| AN924_RS01215 | 245241..245444 | - | 204 | WP_024409202.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 236911..248026 | 11115 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6681.93 Da Isoelectric Point: 10.8207
>T57078 WP_009910449.1 NZ_CP012731:c240522-240340 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL
Download Length: 183 bp
>T57078 NZ_CP012731:c240522-240340 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 16672.68 Da Isoelectric Point: 4.0098
>AT57078 WP_009910448.1 NZ_CP012731:c240300-239848 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
Download Length: 453 bp
>AT57078 NZ_CP012731:c240300-239848 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A123U128 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y6VEQ2 |