Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 239848..240522 Replicon chromosome
Accession NZ_CP012731
Organism Streptococcus suis strain 90-1330

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag AN924_RS01170 Protein ID WP_009910449.1
Coordinates 240340..240522 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag AN924_RS01165 Protein ID WP_009910448.1
Coordinates 239848..240300 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN924_RS01135 235843..236847 + 1005 WP_009910438.1 lactonase family protein -
AN924_RS01140 236911..237096 + 186 WP_002935693.1 hypothetical protein -
AN924_RS01145 237129..237770 - 642 WP_062897072.1 HAD family hydrolase -
AN924_RS01150 237937..238197 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
AN924_RS01155 238199..238420 - 222 WP_012775256.1 hypothetical protein -
AN924_RS01160 239527..239736 - 210 WP_009910447.1 hypothetical protein -
AN924_RS01165 239848..240300 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AN924_RS01170 240340..240522 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
AN924_RS01175 240706..241092 - 387 WP_009910450.1 hypothetical protein -
AN924_RS01180 241232..241732 - 501 WP_024409209.1 hypothetical protein -
AN924_RS01185 241802..242242 - 441 WP_024409208.1 hypothetical protein -
AN924_RS01190 242710..243555 - 846 WP_024409207.1 ATP-binding protein -
AN924_RS01195 243571..244365 - 795 WP_079269917.1 DnaD domain protein -
AN924_RS01200 244379..244594 - 216 WP_024409205.1 hypothetical protein -
AN924_RS11275 244599..244757 - 159 WP_162841287.1 hypothetical protein -
AN924_RS01205 244768..245034 - 267 WP_024409204.1 hypothetical protein -
AN924_RS01210 245045..245248 - 204 WP_024409203.1 hypothetical protein -
AN924_RS01215 245241..245444 - 204 WP_024409202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 236911..248026 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T57078 WP_009910449.1 NZ_CP012731:c240522-240340 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T57078 NZ_CP012731:c240522-240340 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT57078 WP_009910448.1 NZ_CP012731:c240300-239848 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT57078 NZ_CP012731:c240300-239848 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References