57077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 237937..238420 Replicon chromosome
Accession NZ_CP012731
Organism Streptococcus suis strain 90-1330

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag AN924_RS01150 Protein ID WP_009910443.1
Coordinates 237937..238197 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag AN924_RS01155 Protein ID WP_012775256.1
Coordinates 238199..238420 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN924_RS01125 233322..234551 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
AN924_RS01130 234541..235707 - 1167 WP_002935690.1 AI-2E family transporter -
AN924_RS01135 235843..236847 + 1005 WP_009910438.1 lactonase family protein -
AN924_RS01140 236911..237096 + 186 WP_002935693.1 hypothetical protein -
AN924_RS01145 237129..237770 - 642 WP_062897072.1 HAD family hydrolase -
AN924_RS01150 237937..238197 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN924_RS01155 238199..238420 - 222 WP_012775256.1 hypothetical protein Antitoxin
AN924_RS01160 239527..239736 - 210 WP_009910447.1 hypothetical protein -
AN924_RS01165 239848..240300 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
AN924_RS01170 240340..240522 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
AN924_RS01175 240706..241092 - 387 WP_009910450.1 hypothetical protein -
AN924_RS01180 241232..241732 - 501 WP_024409209.1 hypothetical protein -
AN924_RS01185 241802..242242 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 236911..248026 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T57077 WP_009910443.1 NZ_CP012731:c238197-237937 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T57077 NZ_CP012731:c238197-237937 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT57077 WP_012775256.1 NZ_CP012731:c238420-238199 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT57077 NZ_CP012731:c238420-238199 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References