Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316430..2317405 Replicon chromosome
Accession NZ_CP012728
Organism Bacillus anthracis strain PR10-4

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag AOD69_RS12340 Protein ID WP_002036394.1
Coordinates 2316430..2317167 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag AOD69_RS12345 Protein ID WP_000588712.1
Coordinates 2317280..2317405 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOD69_RS12320 2312158..2312940 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
AOD69_RS12325 2313062..2314747 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
AOD69_RS12330 2314854..2315336 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
AOD69_RS12335 2315504..2316241 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
AOD69_RS12340 2316430..2317167 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
AOD69_RS12345 2317280..2317405 + 126 WP_000588712.1 hypothetical protein Antitoxin
AOD69_RS30350 2317482..2317658 + 177 WP_000852614.1 hypothetical protein -
AOD69_RS12355 2317695..2317976 - 282 WP_001041555.1 hypothetical protein -
AOD69_RS12360 2318253..2318489 - 237 WP_001021689.1 hypothetical protein -
AOD69_RS30355 2318828..2319004 + 177 WP_000808045.1 hypothetical protein -
AOD69_RS12370 2319148..2320617 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
AOD69_RS12375 2321181..2321651 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T57072 WP_002036394.1 NZ_CP012728:2316430-2317167 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T57072 NZ_CP012728:2316430-2317167 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT57072 WP_000588712.1 NZ_CP012728:2317280-2317405 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT57072 NZ_CP012728:2317280-2317405 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References