Detailed information of TA system TA057053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 94174..94685
• Replicon: chromosome
• Accession: NZ_CP012715
• Organism: Fusobacterium nucleatum subsp. animalis strain KCOM 1325

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F7L0U8
• Locus tag: RO08_RS00490
• Protein ID: WP_005910516.1
• Coordinates: 94431..94685 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7L0U9
• Locus tag: RO08_RS00485
• Protein ID: WP_005910514.1
• Coordinates: 94174..94431 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RO08_RS00465	89310..91403	+	2094	WP_009007598.1	outer membrane protein assembly factor	-
RO08_RS00470	91444..91917	+	474	WP_005910511.1	OmpH family outer membrane protein	-
RO08_RS00475	91944..92942	+	999	WP_023039698.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
RO08_RS00480	92981..94054	+	1074	WP_005910513.1	glycerophosphodiester phosphodiesterase	-
RO08_RS00485	94174..94431	+	258	WP_005910514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RO08_RS00490	94431..94685	+	255	WP_005910516.1	Txe/YoeB family addiction module toxin	Toxin
RO08_RS00495	94806..95882	+	1077	WP_008701808.1	DHH family phosphoesterase	-
RO08_RS00500	96115..96852	+	738	WP_029597407.1	tRNA pseudouridine(38-40) synthase TruA	-
RO08_RS00505	96993..97568	+	576	WP_005910552.1	aminoacyl-tRNA hydrolase	-
RO08_RS00510	97642..98958	+	1317	WP_005905476.1	electron transport complex subunit RsxC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10007.42 Da
• Isoelectric Point: 8.0154

>T57053 WP_005910516.1 NZ_CP012715:94431-94685 [Fusobacterium nucleatum subsp. animalis]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Nucleotide

• Length: 255 bp

>T57053 NZ_CP012715:94431-94685 [Fusobacterium nucleatum subsp. animalis]
ATGTTATTGACTTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAGAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAACTAAGTG
GTTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10140.41 Da
• Isoelectric Point: 4.7022

>AT57053 WP_005910514.1 NZ_CP012715:94174-94431 [Fusobacterium nucleatum subsp. animalis]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT57053 NZ_CP012715:94174-94431 [Fusobacterium nucleatum subsp. animalis]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Toxin

• AlphaFold DB: F7L0U8

Antitoxin

• AlphaFold DB: F7L0U9