Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1499509..1500016 Replicon chromosome
Accession NZ_CP012714
Organism Fusobacterium nucleatum subsp. vincentii ChDC F8 strain KCOM 1231

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806U495
Locus tag RN99_RS07010 Protein ID WP_029599776.1
Coordinates 1499509..1499769 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag RN99_RS07015 Protein ID WP_005892688.1
Coordinates 1499762..1500016 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN99_RS06985 1495081..1496358 - 1278 WP_099747115.1 D-alanyl-D-alanine carboxypeptidase -
RN99_RS06990 1496442..1496828 - 387 WP_008796539.1 Fe-S cluster assembly scaffold protein NifU -
RN99_RS06995 1496901..1498097 - 1197 WP_029599778.1 cysteine desulfurase NifS -
RN99_RS07000 1498176..1498826 - 651 WP_008803582.1 endonuclease III -
RN99_RS07005 1499004..1499492 - 489 WP_008796536.1 GNAT family N-acetyltransferase -
RN99_RS07010 1499509..1499769 - 261 WP_029599776.1 Txe/YoeB family addiction module toxin Toxin
RN99_RS07015 1499762..1500016 - 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RN99_RS07020 1500144..1501352 - 1209 WP_029599775.1 tyrosine--tRNA ligase -
RN99_RS07025 1501585..1502859 - 1275 WP_029599774.1 branched-chain amino acid transport system II carrier protein -
RN99_RS07030 1503007..1503369 - 363 WP_023035889.1 arsenate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10303.80 Da        Isoelectric Point: 9.3791

>T57052 WP_029599776.1 NZ_CP012714:c1499769-1499509 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MNNLVWTHRAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNENAYSRRIDEKNRLVYRIVDGVIWIIAC
KGHYEE

Download         Length: 261 bp

>T57052 NZ_CP012714:c1499769-1499509 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGAATAATTTAGTATGGACACATAGGGCTTGGCAAGATTACCTATATTGGCAAACTCAGGATAAAAAAACTTTAAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAATGGGATAGGCAAGCCAGAAGTATTAAAAAATGAAA
ATGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGGGTTATATGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT57052 WP_005892688.1 NZ_CP012714:c1500016-1499762 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp

>AT57052 NZ_CP012714:c1500016-1499762 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTAGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAAAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAGGCAGGAAAAGGGGAAATTCACGATTTAATAGAG
GTTGATGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806U495

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References