Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 940535..941060 Replicon chromosome
Accession NZ_CP012714
Organism Fusobacterium nucleatum subsp. vincentii ChDC F8 strain KCOM 1231

Toxin (Protein)


Gene name relE Uniprot ID A0A806UQ73
Locus tag RN99_RS04495 Protein ID WP_008797335.1
Coordinates 940535..940807 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A806UI43
Locus tag RN99_RS04500 Protein ID WP_020789402.1
Coordinates 940800..941060 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN99_RS04470 935789..936331 - 543 WP_029599871.1 5-formyltetrahydrofolate cyclo-ligase -
RN99_RS04475 936324..936911 - 588 WP_029599872.1 uracil-DNA glycosylase family protein -
RN99_RS04480 936921..937703 - 783 WP_005888056.1 MBL fold metallo-hydrolase -
RN99_RS04485 937710..938426 - 717 WP_029599873.1 SDR family NAD(P)-dependent oxidoreductase -
RN99_RS04490 938639..940510 - 1872 WP_029599874.1 spore photoproduct lyase -
RN99_RS04495 940535..940807 - 273 WP_008797335.1 type II toxin-antitoxin system YafQ family toxin Toxin
RN99_RS04500 940800..941060 - 261 WP_020789402.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RN99_RS04505 941307..941594 - 288 Protein_855 MmcQ/YjbR family DNA-binding protein -
RN99_RS04510 941697..943004 + 1308 WP_029599880.1 hypothetical protein -
RN99_RS04515 942997..944580 + 1584 WP_029599881.1 hypothetical protein -
RN99_RS04520 944673..945209 - 537 WP_008799369.1 YcxB family protein -
RN99_RS04525 945240..945662 - 423 WP_005888030.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10759.60 Da        Isoelectric Point: 9.3533

>T57051 WP_008797335.1 NZ_CP012714:c940807-940535 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MLKIKYHTKFKKDYKLIIKRGYNLKLLEEIIDNLANEKTLLPKNKDHSLTGNYEGFRECHITPDWLLIYRIEENNLILVL
LRTGTHSDLF

Download         Length: 273 bp

>T57051 NZ_CP012714:c940807-940535 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGCTTAAAATCAAATATCACACTAAATTTAAAAAAGACTATAAACTTATAATAAAAAGAGGTTACAATTTAAAATTATT
AGAAGAAATTATTGATAATTTGGCAAATGAAAAGACTTTATTACCTAAAAATAAAGATCATAGTTTAACTGGAAATTATG
AAGGATTTAGAGAATGTCATATAACTCCTGATTGGCTATTAATTTATAGAATAGAAGAAAATAATCTTATATTAGTTTTA
TTGAGAACAGGAACTCATTCTGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9820.30 Da        Isoelectric Point: 4.8408

>AT57051 WP_020789402.1 NZ_CP012714:c941060-940800 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MAQVSVTVKTDEEIKKDFNTFCEEIGLNMSTAINLFMRAVLREKRIPFELSLSNNETIQVFKDVKEGKNLSKSFSSVKEL
MEDLNA

Download         Length: 261 bp

>AT57051 NZ_CP012714:c941060-940800 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGGCACAAGTTAGTGTAACAGTAAAAACGGATGAAGAAATAAAAAAAGATTTTAATACTTTTTGTGAAGAAATTGGTTT
AAATATGTCAACTGCTATAAATTTATTTATGAGAGCTGTTTTAAGAGAAAAAAGAATTCCTTTTGAACTTAGCTTATCTA
ATAATGAAACTATACAAGTTTTTAAAGATGTAAAAGAAGGTAAAAATTTAAGTAAGTCATTTAGTTCTGTTAAAGAATTA
ATGGAGGACTTAAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806UQ73

Antitoxin

Source ID Structure
AlphaFold DB A0A806UI43

References