Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 153155..153669 Replicon chromosome
Accession NZ_CP012714
Organism Fusobacterium nucleatum subsp. vincentii ChDC F8 strain KCOM 1231

Toxin (Protein)


Gene name relB Uniprot ID A0A806U886
Locus tag RN99_RS00770 Protein ID WP_005911996.1
Coordinates 153412..153669 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A806U1B6
Locus tag RN99_RS00765 Protein ID WP_029598877.1
Coordinates 153155..153412 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN99_RS00745 148294..150387 + 2094 WP_070627470.1 outer membrane protein assembly factor -
RN99_RS00750 150428..150901 + 474 WP_005892890.1 OmpH family outer membrane protein -
RN99_RS00755 150924..151922 + 999 WP_023035775.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
RN99_RS00760 151965..153035 + 1071 WP_029598876.1 glycerophosphodiester phosphodiesterase -
RN99_RS00765 153155..153412 + 258 WP_029598877.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RN99_RS00770 153412..153669 + 258 WP_005911996.1 Txe/YoeB family addiction module toxin Toxin
RN99_RS00775 153785..154861 + 1077 WP_029598879.1 DHH family phosphoesterase -
RN99_RS00780 155093..155830 + 738 WP_029598881.1 tRNA pseudouridine(38-40) synthase TruA -
RN99_RS00785 155972..156547 + 576 WP_029598883.1 aminoacyl-tRNA hydrolase -
RN99_RS00790 156621..157928 + 1308 WP_005911992.1 electron transport complex subunit RsxC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10207.79 Da        Isoelectric Point: 9.3654

>T57050 WP_005911996.1 NZ_CP012714:153412-153669 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MLLTWTDFAWEQYEELQEKDKRLVKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDYKNRLVYKISDTQIIIVAC
ANHYK

Download         Length: 258 bp

>T57050 NZ_CP012714:153412-153669 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGTTATTGACCTGGACTGATTTTGCATGGGAACAATATGAAGAATTACAGGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATATCCTTATTAAGGATATAAAAAGGAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAGCTAAGTG
GCTATTGGAGTAGAAGAATTGATTATAAAAATAGATTAGTTTATAAGATATCAGATACTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10154.44 Da        Isoelectric Point: 4.7022

>AT57050 WP_029598877.1 NZ_CP012714:153155-153412 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEVEKGNVKEHD
LVEVD

Download         Length: 258 bp

>AT57050 NZ_CP012714:153155-153412 [Fusobacterium nucleatum subsp. vincentii ChDC F8]
ATGATAGCAACTAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAAGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGTTGAAAAGGGTAATGTTAAAGAACATGAT
TTAGTAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806U886

Antitoxin

Source ID Structure
AlphaFold DB A0A806U1B6

References