57049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 382533..383104 Replicon chromosome
Accession NZ_CP012713
Organism Fusobacterium nucleatum subsp. animalis strain KCOM 1279

Toxin (Protein)


Gene name mazF Uniprot ID A0A140PSE3
Locus tag RN98_RS02020 Protein ID WP_008701956.1
Coordinates 382781..383104 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A140PUK7
Locus tag RN98_RS02015 Protein ID WP_008701954.1
Coordinates 382533..382787 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RN98_RS02000 378048..378467 - 420 WP_060675704.1 NfeD family protein -
RN98_RS02005 378709..380178 + 1470 WP_060675705.1 N-acetylglucosamine-specific PTS transporter subunit IIBC -
RN98_RS02010 380265..382331 + 2067 WP_060675706.1 elongation factor G -
RN98_RS02015 382533..382787 + 255 WP_008701954.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RN98_RS02020 382781..383104 + 324 WP_008701956.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RN98_RS02025 383233..383517 - 285 WP_005910587.1 ferredoxin family protein -
RN98_RS02030 383520..384815 - 1296 WP_008693338.1 FAD-dependent oxidoreductase -
RN98_RS02035 384839..385534 - 696 WP_060675707.1 ubiquinone/menaquinone biosynthesis methyltransferase -
RN98_RS02040 385536..386459 - 924 WP_060675708.1 UbiA family prenyltransferase -
RN98_RS02045 386456..387436 - 981 WP_060675709.1 polyprenyl synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-106)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12437.59 Da        Isoelectric Point: 8.0539

>T57049 WP_008701956.1 NZ_CP012713:382781-383104 [Fusobacterium nucleatum subsp. animalis]
VVERGDIIIINFDPVKGHEQAGKRPALVISNEKFYRIFKLAVILPITNNTKDFPFHVLLDDRTNIKGVILCEHLRTVDLE
ERKYNKVEKLPKNLLEEVLEKVSLIFQ

Download         Length: 324 bp

>T57049 NZ_CP012713:382781-383104 [Fusobacterium nucleatum subsp. animalis]
GTGGTAGAAAGAGGAGATATTATTATAATAAATTTTGATCCTGTAAAAGGACATGAACAAGCAGGGAAAAGGCCAGCATT
GGTTATCAGTAATGAGAAATTTTATAGAATATTTAAATTAGCAGTAATTCTTCCAATAACAAATAATACAAAAGATTTTC
CATTTCACGTGCTATTAGATGATAGAACAAATATAAAAGGTGTAATATTATGTGAACATTTAAGAACAGTTGATTTAGAA
GAAAGAAAATACAATAAAGTTGAAAAATTACCAAAAAATCTGTTAGAAGAAGTTCTTGAAAAAGTGAGCTTAATTTTTCA
ATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10117.64 Da        Isoelectric Point: 8.4038

>AT57049 WP_008701954.1 NZ_CP012713:382533-382787 [Fusobacterium nucleatum subsp. animalis]
MEVLRVQKWGNSQGIRLPKKILKDLKIDINDKIEISLNGEEIILKKVKKYTSLDDLFKDYRGDYRKDFDEFEFFGEAQGR
EFKW

Download         Length: 255 bp

>AT57049 NZ_CP012713:382533-382787 [Fusobacterium nucleatum subsp. animalis]
ATGGAAGTATTAAGAGTTCAAAAATGGGGAAATAGTCAAGGAATTAGATTACCTAAAAAAATTTTAAAAGATTTAAAAAT
AGATATAAATGATAAAATTGAAATAAGTTTAAATGGAGAAGAAATTATACTAAAAAAAGTAAAAAAATATACTAGTTTAG
ATGATTTATTTAAAGATTATAGAGGAGACTATAGAAAAGATTTTGATGAATTTGAATTTTTTGGAGAAGCACAAGGTCGT
GAATTTAAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140PSE3

Antitoxin

Source ID Structure
AlphaFold DB A0A140PUK7

References