Detailed information of TA system TA057048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 290268..290779
• Replicon: chromosome
• Accession: NZ_CP012713
• Organism: Fusobacterium nucleatum subsp. animalis strain KCOM 1279

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F7L0U8
• Locus tag: RN98_RS01435
• Protein ID: WP_005910516.1
• Coordinates: 290525..290779 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7L0U9
• Locus tag: RN98_RS01430
• Protein ID: WP_005910514.1
• Coordinates: 290268..290525 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RN98_RS01410	285403..287496	+	2094	WP_005910510.1	outer membrane protein assembly factor	-
RN98_RS01415	287537..288010	+	474	WP_005910511.1	OmpH family outer membrane protein	-
RN98_RS01420	288038..289036	+	999	WP_005910512.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
RN98_RS01425	289075..290148	+	1074	WP_060675636.1	glycerophosphodiester phosphodiesterase	-
RN98_RS01430	290268..290525	+	258	WP_005910514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RN98_RS01435	290525..290779	+	255	WP_005910516.1	Txe/YoeB family addiction module toxin	Toxin
RN98_RS01440	290900..291976	+	1077	WP_060675637.1	DHH family phosphoesterase	-
RN98_RS01445	292217..292954	+	738	WP_060675638.1	tRNA pseudouridine(38-40) synthase TruA	-
RN98_RS01450	293095..293670	+	576	WP_060675639.1	aminoacyl-tRNA hydrolase	-
RN98_RS01455	293744..295060	+	1317	WP_060675640.1	electron transport complex subunit RsxC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	277604..346358	68754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10007.42 Da
• Isoelectric Point: 8.0154

>T57048 WP_005910516.1 NZ_CP012713:290525-290779 [Fusobacterium nucleatum subsp. animalis]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Nucleotide

• Length: 255 bp

>T57048 NZ_CP012713:290525-290779 [Fusobacterium nucleatum subsp. animalis]
ATGTTATTAACGTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAGAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCTGAACCTTTACAACATGAATTAAGTG
GTTATTGGAGTAGACGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10140.41 Da
• Isoelectric Point: 4.7022

>AT57048 WP_005910514.1 NZ_CP012713:290268-290525 [Fusobacterium nucleatum subsp. animalis]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT57048 NZ_CP012713:290268-290525 [Fusobacterium nucleatum subsp. animalis]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Toxin

• AlphaFold DB: F7L0U8

Antitoxin

• AlphaFold DB: F7L0U9