Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 276232..276926 Replicon chromosome
Accession NZ_CP012712
Organism Parageobacillus thermoglucosidasius strain DSM 2542

Toxin (Protein)


Gene name mazF Uniprot ID A0A369X1P3
Locus tag AOT13_RS01390 Protein ID WP_042384676.1
Coordinates 276232..276618 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A369X4Q0
Locus tag AOT13_RS01395 Protein ID WP_042384678.1
Coordinates 276618..276926 (-) Length 103 a.a.

Genomic Context

AOT13_RS01365AOT13_RS01370AOT13_RS01375AOT13_RS01380AOT13_RS19265AOT13_RS19990AOT13_RS01410AOT13_RS19995AOT13_RS01415AOT13_RS01385AOT13_RS01390AOT13_RS01395AOT13_RS01400AOT13_RS01405
Location: 271980..272663 (684 bp)
Type: Others
Protein ID: WP_042384671.1
Location: 272683..273051 (369 bp)
Type: Others
Protein ID: WP_042384673.1
Location: 273038..273406 (369 bp)
Type: Others
Protein ID: WP_041270157.1
Location: 273423..274688 (1266 bp)
Type: Others
Protein ID: WP_042384675.1
Location: 277575..278045 (471 bp)
Type: Others
Protein ID: WP_003247869.1
Location: 278182..278334 (153 bp)
Type: Others
Protein ID: WP_153017391.1
Location: 280794..281033 (240 bp)
Type: Others
Protein ID: WP_035501703.1
Location: 281243..281348 (106 bp)
Type: Others
Protein ID: Protein_280
Location: 281390..281704 (315 bp)
Type: Others
Protein ID: WP_072000118.1
Location: 275150..276040 (891 bp)
Type: Others
Protein ID: WP_042384703.1
Location: 276232..276618 (387 bp)
Type: Toxin
Protein ID: WP_042384676.1
Location: 276618..276926 (309 bp)
Type: Antitoxin
Protein ID: WP_042384678.1
Location: 278380..279102 (723 bp)
Type: Others
Protein ID: WP_080695333.1
Location: 279103..280608 (1506 bp)
Type: Others
Protein ID: WP_042384708.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOT13_RS01365271980..272663+684WP_042384671.1glycosyltransferase family 2 protein-
AOT13_RS01370272683..273051+369WP_042384673.1DUF2304 domain-containing protein-
AOT13_RS01375273038..273406+369WP_041270157.1EamA family transporter-
AOT13_RS01380273423..274688+1266WP_042384675.1glycosyltransferase family 39 protein-
AOT13_RS01385275150..276040-891WP_042384703.1ISNCY family transposase-
AOT13_RS01390276232..276618-387WP_042384676.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AOT13_RS01395276618..276926-309WP_042384678.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
AOT13_RS19265277575..278045+471WP_003247869.1transposase family protein-
AOT13_RS19990278182..278334+153WP_153017391.1hypothetical protein-
AOT13_RS01400278380..279102-723WP_080695333.1IS21-like element helper ATPase IstB-
AOT13_RS01405279103..280608-1506WP_042384708.1IS21 family transposase-
AOT13_RS01410280794..281033+240WP_035501703.1hypothetical protein-
AOT13_RS19995281243..281348+106Protein_280helix-turn-helix domain-containing protein-
AOT13_RS01415281390..281704+315WP_072000118.1ATP-binding protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin

Antitoxin PemI-like

(23-100)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14285.31 Da        Isoelectric Point: 4.6190

>T57046 WP_042384676.1 NZ_CP012712:c276618-276232 [Parageobacillus thermoglucosidasius]
MPADVPERGDFVVLNFNPQAGHEQAGRRNAIVLSPKEFNQATGFIAVCPIINQKKGYPFEVDLPKEGISPDGDGYPITGV
VLTDQIKSLDWKARNLKILKKYNPEDAQIEEIDKIIDECLAKIETYLT

Download         Length: 387 bp

>T57046 NZ_CP012712:c276618-276232 [Parageobacillus thermoglucosidasius]
ATGCCAGCAGACGTACCAGAGAGAGGCGATTTCGTTGTTTTAAACTTCAATCCACAAGCTGGTCATGAGCAGGCTGGGAG
AAGGAATGCTATTGTTTTATCGCCTAAAGAATTCAATCAAGCAACAGGATTTATAGCTGTTTGTCCGATTATCAATCAAA
AGAAGGGTTATCCCTTCGAAGTGGATTTACCAAAAGAAGGAATATCCCCTGATGGCGATGGCTATCCAATAACAGGGGTA
GTTTTAACTGATCAAATTAAATCATTGGATTGGAAAGCTCGTAATCTAAAAATTTTAAAAAAGTATAATCCAGAAGATGC
ACAAATTGAAGAAATAGATAAAATCATTGATGAATGCCTAGCGAAAATAGAAACATATCTGACTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11578.31 Da        Isoelectric Point: 8.4665

>AT57046 WP_042384678.1 NZ_CP012712:c276926-276618 [Parageobacillus thermoglucosidasius]
MYSKEHLENKINQSKGVGYMSTVIVQKWGNSLGIRIPKDAADKIGIKQGSEIELNVIGNEGIITLKPKRTRKKYTLEELI
SQITPENRHEEIDFGIEGRELI

Download         Length: 309 bp

>AT57046 NZ_CP012712:c276926-276618 [Parageobacillus thermoglucosidasius]
ATGTATTCAAAAGAACATTTAGAAAACAAGATAAACCAGAGTAAAGGGGTTGGCTACATGTCTACAGTTATTGTTCAAAA
ATGGGGAAACAGTTTGGGCATTCGTATCCCAAAAGATGCTGCTGATAAAATAGGGATTAAACAAGGTTCCGAAATAGAAT
TAAATGTGATTGGAAATGAAGGTATCATCACATTAAAGCCAAAAAGAACACGGAAGAAATACACACTGGAAGAACTAATA
TCACAGATTACACCTGAAAATCGACACGAGGAAATTGATTTCGGGATAGAAGGGCGTGAATTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A369X1P3

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A369X4Q0

References