Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-relB/COG4683-DinJ
Location 12240..12942 Replicon plasmid 3
Accession NZ_CP012709
Organism Psychrobacter urativorans strain R310.10B

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4U6T6
Locus tag AOC03_RS12170 Protein ID WP_062536857.1
Coordinates 12595..12942 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M5MNY6
Locus tag AOC03_RS12165 Protein ID WP_062536855.1
Coordinates 12240..12473 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC03_RS12150 7299..9932 - 2634 WP_062536851.1 MobA/MobL family protein -
AOC03_RS12155 10194..10505 + 312 WP_062536853.1 hypothetical protein -
AOC03_RS12160 11202..12155 + 954 WP_084785921.1 replication initiation protein -
AOC03_RS12165 12240..12473 + 234 WP_062536855.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AOC03_RS12170 12595..12942 + 348 WP_062536857.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOC03_RS12175 12944..13246 + 303 WP_062536859.1 XRE family transcriptional regulator -
AOC03_RS12180 13473..14093 - 621 WP_062536861.1 recombinase family protein -
AOC03_RS12185 14285..15058 - 774 WP_062536863.1 type I methionyl aminopeptidase -
AOC03_RS12190 15051..15257 - 207 WP_062536865.1 ParD-like family protein -
AOC03_RS12195 15498..16025 - 528 WP_062536867.1 Rrf2 family transcriptional regulator -
AOC03_RS12200 16479..17108 + 630 WP_062536869.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..24210 24210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-69)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13353.36 Da        Isoelectric Point: 7.8517

>T57044 WP_062536857.1 NZ_CP012709:12595-12942 [Psychrobacter urativorans]
MWTVITTELFNQWFDQQDESTQEKVLAALVVLEQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPKRQAI
VLCIGDKGNKKRFYKEMLATADQQYECHLKTLGDL

Download         Length: 348 bp

>T57044 NZ_CP012709:12595-12942 [Psychrobacter urativorans]
ATGTGGACTGTCATCACAACAGAGCTGTTCAACCAATGGTTTGATCAGCAAGACGAATCAACGCAAGAAAAAGTGCTGGC
AGCTTTGGTGGTTTTAGAACAGCAAGGCCCAAGCTTAGGTCGTCCTTTAGTGGATACGGTGTATGATTCAAAATTTACCA
ACATGAAAGAGTTACGTGTTCAGCACCGAGGTAAACCACTCAGAGCCTTTTTTGCCTTTGATCCAAAGCGACAAGCGATT
GTGCTTTGTATCGGTGATAAGGGTAATAAAAAGCGTTTTTATAAAGAAATGCTAGCCACTGCAGACCAGCAGTATGAGTG
TCATCTTAAAACCTTAGGAGATCTATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8621.73 Da        Isoelectric Point: 4.5379

>AT57044 WP_062536855.1 NZ_CP012709:12240-12473 [Psychrobacter urativorans]
MTTTNYNIRLEQELKDSAFSVFESYGLTPSQAIKLFLTQVAQTNTVPLSFDYQARANVKTLDEALETKAVMNTVVSQ

Download         Length: 234 bp

>AT57044 NZ_CP012709:12240-12473 [Psychrobacter urativorans]
ATGACCACTACCAATTATAATATCCGACTTGAACAGGAACTCAAAGACAGTGCTTTCTCTGTGTTTGAAAGCTATGGTTT
AACACCGTCTCAGGCGATTAAATTATTCCTCACGCAAGTGGCGCAGACCAATACAGTGCCGCTATCTTTTGACTATCAAG
CAAGGGCTAACGTCAAGACGCTAGATGAGGCGCTAGAAACCAAAGCTGTCATGAACACTGTCGTCAGCCAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4U6T6

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5MNY6

References