Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1491378..1492851 Replicon chromosome
Accession NZ_CP012700
Organism Sphingopyxis macrogoltabida strain EY-1

Toxin (Protein)


Gene name rlegT Uniprot ID A0A0N7GS99
Locus tag AN936_RS06965 Protein ID WP_054587503.1
Coordinates 1491378..1492241 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A0N9U9L6
Locus tag AN936_RS06970 Protein ID WP_054587504.1
Coordinates 1492234..1492851 (-) Length 206 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN936_RS24640 1486476..1486691 + 216 WP_149037615.1 DUF1289 domain-containing protein -
AN936_RS24645 1486762..1486995 - 234 WP_149037616.1 hypothetical protein -
AN936_RS06945 1487166..1487501 + 336 WP_054587499.1 single-stranded DNA-binding protein -
AN936_RS06950 1487971..1488495 + 525 WP_054587500.1 hypothetical protein -
AN936_RS06955 1488495..1489553 + 1059 WP_149037617.1 relaxase/mobilization nuclease domain-containing protein -
AN936_RS06960 1489555..1491303 - 1749 WP_054587502.1 recombinase family protein -
AN936_RS06965 1491378..1492241 - 864 WP_054587503.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
AN936_RS06970 1492234..1492851 - 618 WP_054587504.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
AN936_RS06975 1492959..1493744 - 786 WP_054587505.1 hypothetical protein -
AN936_RS06980 1493734..1495572 - 1839 WP_084758225.1 type IV secretory system conjugative DNA transfer family protein -
AN936_RS06985 1495544..1496554 - 1011 WP_054587507.1 P-type DNA transfer ATPase VirB11 -
AN936_RS06990 1496554..1497744 - 1191 WP_054587508.1 type IV secretion system protein VirB10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1468780..1514865 46085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-260)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(10-54)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 31677.37 Da        Isoelectric Point: 4.7387

>T57040 WP_054587503.1 NZ_CP012700:c1492241-1491378 [Sphingopyxis macrogoltabida]
MAETPANIAASAKARLLALARAEGQPFDVLLVRFALERLLYRLSISPQRDDFILKGGLLVTLWLEDSNRVTRDMDFLAFG
DASAARLIADFGGIMAVEADDGLMFDIERLTARPIREEAEYGGMRLSTIAHLERTRIPVTIDLGFGDVIARPADPVAYPT
LLDFPDPEIRVYPPATVIAEKFQAMVALGIANSRMKDYYDLWALPRSCPITADDLDAAIAATFERRGTKVPTEPPPGLSN
SFFEDRDKQRQWAAYAGSIDLARVQLDAVVHQIWNLVGPSCARLTKA

Download         Length: 864 bp

>T57040 NZ_CP012700:c1492241-1491378 [Sphingopyxis macrogoltabida]
ATGGCTGAGACACCGGCGAACATCGCTGCCTCCGCCAAAGCGCGCCTGCTCGCGCTCGCGCGCGCGGAAGGCCAGCCCTT
CGACGTGCTGCTCGTGCGCTTCGCGCTCGAACGCCTGCTCTACCGGCTCTCGATTTCTCCACAGCGCGACGATTTCATTC
TCAAGGGCGGTCTGCTCGTGACCTTGTGGCTGGAAGACAGCAACCGTGTCACGCGCGATATGGACTTTCTAGCGTTCGGA
GACGCGAGCGCAGCCCGGTTGATTGCCGATTTCGGTGGAATTATGGCAGTAGAGGCGGACGACGGACTGATGTTCGACAT
CGAACGCCTGACCGCCAGACCGATCCGCGAGGAGGCCGAATATGGCGGCATGCGCCTTTCAACGATCGCACATCTCGAGC
GAACTCGGATTCCGGTGACGATCGATCTCGGCTTTGGCGACGTGATTGCGAGGCCAGCCGATCCGGTCGCCTATCCGACC
TTGCTCGACTTTCCCGATCCCGAGATTCGCGTTTATCCGCCAGCTACGGTGATTGCCGAGAAGTTCCAAGCGATGGTGGC
GCTCGGCATCGCCAACAGCCGGATGAAAGACTATTACGACCTTTGGGCACTTCCGCGTTCCTGCCCGATCACAGCTGACG
ATCTCGACGCGGCGATAGCGGCGACGTTCGAGCGGCGTGGCACCAAAGTCCCAACGGAGCCGCCTCCCGGACTTTCAAAC
AGCTTCTTCGAGGATCGCGACAAGCAACGCCAATGGGCCGCCTATGCCGGCAGCATCGACCTTGCGCGCGTCCAGCTCGA
TGCCGTCGTGCATCAAATCTGGAATCTTGTCGGGCCGTCGTGCGCCAGGCTGACGAAAGCCTGA

Antitoxin


Download         Length: 206 a.a.        Molecular weight: 22367.79 Da        Isoelectric Point: 9.9476

>AT57040 WP_054587504.1 NZ_CP012700:c1492851-1492234 [Sphingopyxis macrogoltabida]
MALITSQRDKLKSLFEKRPILRARELRAAGIAAETIARAVDEGDIDRIARGLYQGADADINADQNLAEVAKRIPKGVIAM
VSALAYHGLTDQMPRRVWVAIGTSDWAPTSTHPPLKIVRFADKYLKQGVAYHEISGVEVPIYSIPKTLADLFRNARLADR
SVAIEGLRSALDQRKTTPSEIAEAAVAGGAWKVMKPYLEALTAHG

Download         Length: 618 bp

>AT57040 NZ_CP012700:c1492851-1492234 [Sphingopyxis macrogoltabida]
ATGGCGCTCATCACGTCCCAACGGGATAAGCTCAAATCGCTATTCGAGAAGCGGCCAATCCTGCGCGCGCGCGAACTGCG
CGCAGCCGGGATCGCGGCAGAGACGATCGCGCGCGCGGTCGACGAGGGCGATATCGACCGGATCGCGCGCGGGCTCTATC
AAGGTGCCGATGCGGACATCAACGCTGACCAAAACCTTGCCGAAGTCGCCAAGCGCATACCGAAAGGCGTGATCGCGATG
GTTTCCGCCCTCGCCTATCATGGCCTGACCGACCAGATGCCGCGGCGCGTCTGGGTAGCGATCGGCACATCGGACTGGGC
GCCGACCTCGACCCATCCCCCGCTGAAGATCGTCAGGTTCGCAGACAAATATCTGAAGCAAGGCGTCGCATACCACGAAA
TTTCGGGCGTCGAGGTGCCCATCTACTCGATTCCCAAGACGCTCGCGGATCTCTTCCGTAATGCTCGGCTCGCCGACCGC
TCGGTCGCGATCGAAGGACTGCGATCGGCGCTCGATCAACGCAAGACGACGCCGAGCGAAATCGCGGAGGCAGCCGTTGC
CGGTGGTGCATGGAAGGTGATGAAGCCCTATCTGGAGGCACTGACCGCGCATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7GS99

Antitoxin

Source ID Structure
AlphaFold DB A0A0N9U9L6

References