Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1761928..1762562 Replicon chromosome
Accession NZ_CP012697
Organism Microbacterium sp. No. 7

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0EER4
Locus tag AOA12_RS08045 Protein ID WP_054681817.1
Coordinates 1762143..1762562 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0E5E0
Locus tag AOA12_RS08040 Protein ID WP_054681815.1
Coordinates 1761928..1762152 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOA12_RS08015 1758033..1758617 - 585 WP_054681806.1 DNA polymerase III subunit epsilon -
AOA12_RS08020 1758695..1759444 + 750 WP_054681808.1 class I SAM-dependent methyltransferase -
AOA12_RS08025 1759493..1760566 + 1074 WP_054681810.1 redox-regulated ATPase YchF -
AOA12_RS08030 1760672..1761088 - 417 WP_054681812.1 hypothetical protein -
AOA12_RS22545 1761264..1761416 + 153 WP_082406078.1 toxin-antitoxin system -
AOA12_RS22550 1761413..1761781 + 369 WP_082406079.1 PIN domain-containing protein -
AOA12_RS08040 1761928..1762152 + 225 WP_054681815.1 ribbon-helix-helix protein, CopG family Antitoxin
AOA12_RS08045 1762143..1762562 + 420 WP_054681817.1 PIN domain nuclease Toxin
AOA12_RS08050 1762759..1763625 + 867 WP_054681820.1 AraC family transcriptional regulator -
AOA12_RS08055 1763964..1764566 + 603 WP_156366650.1 mismatch-specific DNA-glycosylase -
AOA12_RS08060 1764620..1765306 - 687 WP_054681824.1 type 1 glutamine amidotransferase domain-containing protein -
AOA12_RS08065 1765477..1766181 + 705 Protein_1630 glutamine amidotransferase -
AOA12_RS23550 1766161..1766478 + 318 WP_197281152.1 antibiotic biosynthesis monooxygenase -
AOA12_RS08070 1766581..1767045 + 465 WP_054681826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15097.42 Da        Isoelectric Point: 6.4749

>T57037 WP_054681817.1 NZ_CP012697:1762143-1762562 [Microbacterium sp. No. 7]
VAVTSWLIDKSAYVRMQSGQALNIAEWNARIERGLVRISTVTRLELGFSARSGGAGREAFGLPPLSLMPIEHLSPAMEDR
AFEVQMLLADRGQHRAASIPDLLIAATAEKVGLTVLAVDKDFDLIAQTTGQRVETLALR

Download         Length: 420 bp

>T57037 NZ_CP012697:1762143-1762562 [Microbacterium sp. No. 7]
GTGGCGGTGACGAGTTGGCTCATCGACAAGTCCGCCTACGTGCGGATGCAGTCGGGGCAAGCGCTGAACATCGCAGAATG
GAACGCGCGGATCGAGCGCGGTCTGGTTCGCATCTCGACCGTGACGAGGCTGGAACTCGGCTTCTCGGCGCGCTCAGGTG
GGGCAGGCCGCGAGGCGTTCGGTCTGCCGCCGTTGTCGCTCATGCCGATCGAGCACCTGAGCCCCGCGATGGAGGACCGC
GCGTTCGAGGTTCAGATGCTGCTTGCCGATCGCGGACAGCATCGTGCCGCCTCCATCCCGGACCTTCTCATCGCGGCAAC
TGCGGAAAAGGTCGGGCTGACGGTTCTCGCGGTTGACAAGGACTTCGATCTGATCGCCCAGACCACCGGCCAACGGGTGG
AAACGCTGGCGCTGAGGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7963.96 Da        Isoelectric Point: 4.3148

>AT57037 WP_054681815.1 NZ_CP012697:1761928-1762152 [Microbacterium sp. No. 7]
MTNVLIRGLSDAAVERIDAEAAALGLSRNEFLRRRLELEASAAMVATVTADDWNRSAATFGDLADPGVMDAAWR

Download         Length: 225 bp

>AT57037 NZ_CP012697:1761928-1762152 [Microbacterium sp. No. 7]
ATGACGAACGTGCTGATTCGCGGACTGAGCGATGCCGCTGTCGAGCGGATCGATGCGGAGGCGGCCGCGCTGGGGCTGTC
TCGCAACGAGTTCCTTCGACGTCGGCTTGAGCTGGAGGCGTCTGCGGCGATGGTCGCCACGGTTACCGCCGATGACTGGA
ATCGATCTGCCGCGACCTTCGGCGACCTCGCCGATCCCGGAGTCATGGACGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0EER4

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0E5E0

References