Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3583410..3583888 Replicon chromosome
Accession NZ_CP012693
Organism Escherichia coli strain FORC_028

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FORC28_RS18860 Protein ID WP_001303876.1
Coordinates 3583601..3583888 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FORC28_RS18855 Protein ID WP_000536233.1
Coordinates 3583410..3583601 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC28_RS18820 3578792..3579562 - 771 WP_032324560.1 DUF1627 domain-containing protein -
FORC28_RS18825 3579588..3580328 - 741 WP_021498074.1 ATP-binding protein -
FORC28_RS18830 3580335..3581450 - 1116 WP_001205820.1 hypothetical protein -
FORC28_RS32420 3581529..3581984 + 456 WP_000273724.1 hypothetical protein -
FORC28_RS18840 3582191..3582616 - 426 WP_000693855.1 Rha family transcriptional regulator -
FORC28_RS18845 3582600..3582872 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FORC28_RS18850 3582981..3583382 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FORC28_RS18855 3583410..3583601 + 192 WP_000536233.1 hypothetical protein Antitoxin
FORC28_RS18860 3583601..3583888 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC28_RS18865 3584165..3584317 + 153 WP_000379552.1 DUF1391 family protein -
FORC28_RS18870 3584329..3584967 + 639 WP_000394543.1 hypothetical protein -
FORC28_RS18875 3584968..3585177 - 210 WP_001133037.1 hypothetical protein -
FORC28_RS18885 3585745..3585933 + 189 WP_000413705.1 cell division inhibition protein DicB -
FORC28_RS18890 3585930..3586121 + 192 WP_001098307.1 DUF1482 family protein -
FORC28_RS18895 3586215..3588665 + 2451 WP_009448824.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T57028 WP_001303876.1 NZ_CP012693:3583601-3583888 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T57028 NZ_CP012693:3583601-3583888 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT57028 WP_000536233.1 NZ_CP012693:3583410-3583601 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT57028 NZ_CP012693:3583410-3583601 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References