Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2171064..2171602 Replicon chromosome
Accession NZ_CP012692
Organism Staphylococcus aureus strain FORC_027

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag FORC27_RS11105 Protein ID WP_001078344.1
Coordinates 2171064..2171390 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag FORC27_RS11110 Protein ID WP_001058495.1
Coordinates 2171393..2171602 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC27_RS11080 2166288..2166629 - 342 WP_001190615.1 hypothetical protein -
FORC27_RS11085 2167079..2167720 - 642 WP_001047698.1 hypothetical protein -
FORC27_RS11090 2167717..2168097 - 381 WP_000356942.1 hypothetical protein -
FORC27_RS11095 2168407..2170116 - 1710 WP_000447473.1 DUF927 domain-containing protein -
FORC27_RS11100 2170130..2170999 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
FORC27_RS11105 2171064..2171390 - 327 WP_001078344.1 DUF1474 family protein Toxin
FORC27_RS11110 2171393..2171602 - 210 WP_001058495.1 hypothetical protein Antitoxin
FORC27_RS11115 2171595..2171741 - 147 WP_000784885.1 hypothetical protein -
FORC27_RS11120 2171738..2172055 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
FORC27_RS11125 2172060..2172278 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
FORC27_RS11130 2172451..2173125 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
FORC27_RS11135 2173139..2174311 + 1173 WP_000179343.1 site-specific integrase -
FORC27_RS11140 2174380..2175996 - 1617 WP_000240642.1 chaperonin GroEL -
FORC27_RS11145 2176072..2176356 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec / tsst-1 / groEL 2156874..2176356 19482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T56992 WP_001078344.1 NZ_CP012692:c2171390-2171064 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T56992 NZ_CP012692:c2171390-2171064 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT56992 WP_001058495.1 NZ_CP012692:c2171602-2171393 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT56992 NZ_CP012692:c2171602-2171393 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References