Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878992..879469 Replicon chromosome
Accession NZ_CP012692
Organism Staphylococcus aureus strain FORC_027

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC27_RS04225 Protein ID WP_000052076.1
Coordinates 878992..879180 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC27_RS04230 Protein ID WP_001059690.1
Coordinates 879209..879469 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC27_RS04195 874986..875507 + 522 WP_000824482.1 hypothetical protein -
FORC27_RS04200 875848..876534 + 687 WP_000141557.1 thermonuclease family protein -
FORC27_RS04205 876891..877091 + 201 WP_001059082.1 cold-shock protein -
FORC27_RS04210 877583..877801 - 219 WP_000005886.1 hypothetical protein -
FORC27_RS04215 877863..878147 - 285 WP_044423470.1 hypothetical protein -
FORC27_RS04220 878235..878804 - 570 WP_001106654.1 hypothetical protein -
FORC27_RS04225 878992..879180 - 189 WP_000052076.1 hypothetical protein Toxin
FORC27_RS04230 879209..879469 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC27_RS04235 879810..880013 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC27_RS04240 880010..880246 - 237 WP_000349581.1 hypothetical protein -
FORC27_RS04245 880471..881052 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FORC27_RS04250 881125..881742 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FORC27_RS04255 881897..882391 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC27_RS04260 882790..883212 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC27_RS04265 883360..884076 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T56985 WP_000052076.1 NZ_CP012692:c879180-878992 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T56985 NZ_CP012692:c879180-878992 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT56985 WP_001059690.1 NZ_CP012692:c879469-879209 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT56985 NZ_CP012692:c879469-879209 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References