Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-PumB/COG3657-dnstrm_HI1420
Location 65131..65741 Replicon plasmid unnamed
Accession NZ_CP012688
Organism Ralstonia solanacearum strain UY031

Toxin (Protein)


Gene name relE Uniprot ID B5SAJ5
Locus tag RSUY_RS15980 Protein ID WP_003262835.1
Coordinates 65433..65741 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag RSUY_RS15975 Protein ID WP_003262836.1
Coordinates 65131..65436 (-) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RSUY_RS15955 61238..61648 + 411 WP_003262840.1 acyl-CoA thioesterase -
RSUY_RS15960 61678..62070 + 393 WP_003262838.1 RidA family protein -
RSUY_RS15965 62418..63008 + 591 WP_020957579.1 hypothetical protein -
RSUY_RS15970 63607..64920 - 1314 WP_003262837.1 metabolite/H+ symporter -
RSUY_RS15975 65131..65436 - 306 WP_003262836.1 putative addiction module antidote protein Antitoxin
RSUY_RS15980 65433..65741 - 309 WP_003262835.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RSUY_RS15985 65817..67016 - 1200 WP_003262834.1 MFS transporter -
RSUY_RS15990 67144..67962 - 819 WP_039556864.1 GntR family transcriptional regulator -
RSUY_RS15995 68132..68683 - 552 WP_039556867.1 helix-turn-helix transcriptional regulator -
RSUY_RS16000 68816..69415 + 600 WP_039556871.1 GNAT family N-acetyltransferase -
RSUY_RS16005 69681..70115 + 435 WP_003274507.1 VOC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1999545 1999545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 103 a.a.        Molecular weight: 11900.72 Da        Isoelectric Point: 7.2450

>T56978 WP_003262835.1 NZ_CP012688:c65741-65433 [Ralstonia solanacearum]
MLTIRTTELFDDWFCSLRDKAAQRRIQVRIDRLQMGHLGDMKAVRDGIRELRIDHGPGYRLYFVQHGVVLIVLLCGGDKS
TQETDIRRAIDLSRRLDVDDME

Download         Length: 309 bp

>T56978 NZ_CP012688:c65741-65433 [Ralstonia solanacearum]
ATGCTGACGATCCGCACGACCGAACTCTTTGACGACTGGTTTTGCAGCCTCCGCGACAAGGCTGCGCAACGCCGCATCCA
GGTGCGCATCGACCGCCTGCAGATGGGTCACCTGGGCGACATGAAAGCGGTACGTGACGGCATCCGCGAGCTGCGGATCG
ATCATGGGCCGGGCTACCGCTTGTACTTCGTGCAGCACGGCGTCGTCCTGATCGTACTGCTCTGCGGCGGCGACAAGTCG
ACACAGGAAACCGATATCCGTCGCGCAATTGACCTGTCCCGCCGTCTCGACGTGGACGACATGGAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11038.72 Da        Isoelectric Point: 8.0667

>AT56978 WP_003262836.1 NZ_CP012688:c65436-65131 [Ralstonia solanacearum]
MTMAQRTLKTRPWDSAEHLRTEADMAAYLNACLEEAGDDPAFITHALGVVARARGMTRLARETGITREGLYKALSEDGNP
SFATMLKVIRALGIRLHAVPA

Download         Length: 306 bp

>AT56978 NZ_CP012688:c65436-65131 [Ralstonia solanacearum]
ATGACGATGGCCCAACGCACCCTCAAGACCCGGCCGTGGGATTCGGCCGAACACCTCCGGACCGAGGCGGACATGGCCGC
CTATCTCAACGCCTGCCTGGAAGAAGCCGGGGACGACCCGGCGTTCATTACGCACGCGCTGGGCGTGGTCGCGCGTGCGC
GCGGCATGACCCGGCTCGCCCGCGAGACCGGGATCACGCGCGAAGGGCTGTACAAGGCGCTTTCCGAGGACGGCAACCCG
AGCTTTGCGACCATGCTGAAGGTCATCCGGGCACTCGGCATCCGGCTGCACGCCGTGCCGGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B5SAJ5


Antitoxin

Source ID Structure

References