Detailed information of TA system TA056969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3211893..3212549
• Replicon: chromosome
• Accession: NZ_CP012685
• Organism: Serratia marcescens strain SmUNAM836

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: ABH11_RS15165
• Protein ID: WP_041036282.1
• Coordinates: 3211893..3212282 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: ABH11_RS15170
• Protein ID: WP_004941563.1
• Coordinates: 3212286..3212549 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABH11_RS15150	3208360..3209790	+	1431	WP_060706748.1	multidrug transporter subunit MdtD	-
ABH11_RS15155	3209787..3211169	+	1383	WP_033635541.1	two-component system sensor histidine kinase BaeS	-
ABH11_RS15160	3211169..3211885	+	717	WP_033635542.1	two-component system response regulator BaeR	-
ABH11_RS15165	3211893..3212282	-	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
ABH11_RS15170	3212286..3212549	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ABH11_RS15175	3212889..3213227	+	339	WP_033635544.1	YegP family protein	-
ABH11_RS15180	3213408..3214760	+	1353	WP_060706749.1	tRNA 5-hydroxyuridine modification protein YegQ	-
ABH11_RS15185	3215227..3216132	+	906	WP_033635546.1	lipid kinase YegS	-
ABH11_RS15190	3216299..3217513	+	1215	WP_047570971.1	D-galactonate dehydratase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T56969 WP_041036282.1 NZ_CP012685:c3212282-3211893 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T56969 NZ_CP012685:c3212282-3211893 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAAGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT56969 WP_004941563.1 NZ_CP012685:c3212549-3212286 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT56969 NZ_CP012685:c3212549-3212286 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2