Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 46503..47146 Replicon plasmid p33673_IncF
Accession NZ_CP012683
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 33676

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag SE15cs_RS24375 Protein ID WP_001044768.1
Coordinates 46503..46919 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag SE15cs_RS24380 Protein ID WP_001261287.1
Coordinates 46916..47146 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE15cs_RS24360 41807..42739 - 933 WP_000991832.1 hypothetical protein -
SE15cs_RS24365 42743..43738 - 996 WP_000246636.1 hypothetical protein -
SE15cs_RS24370 44203..46341 + 2139 WP_000350635.1 AAA family ATPase -
SE15cs_RS24375 46503..46919 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
SE15cs_RS24380 46916..47146 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SE15cs_RS24385 47452..50569 + 3118 Protein_46 hypothetical protein -
SE15cs_RS24390 50832..51965 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..112639 112639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T56955 WP_001044768.1 NZ_CP012683:c46919-46503 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T56955 NZ_CP012683:c46919-46503 [Salmonella enterica subsp. enterica serovar Typhimurium]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT56955 WP_001261287.1 NZ_CP012683:c47146-46916 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT56955 NZ_CP012683:c47146-46916 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References