Detailed information of TA system TA056946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 152806..153311
• Replicon: chromosome
• Accession: NZ_CP012679
• Organism: Pseudomonas aeruginosa strain PA1RG

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AOD73_RS00665
• Protein ID: WP_023518248.1
• Coordinates: 152806..153087 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: AOD73_RS00670
• Protein ID: WP_003083775.1
• Coordinates: 153084..153311 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOD73_RS00640	148057..149406	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
AOD73_RS00645	149455..150141	+	687	WP_003083762.1	FadR family transcriptional regulator	-
AOD73_RS00650	150242..150976	+	735	WP_003117208.1	GntR family transcriptional regulator	-
AOD73_RS00655	151180..151566	+	387	WP_014602345.1	aegerolysin family protein	-
AOD73_RS00660	151598..152506	-	909	WP_003083769.1	LysR family transcriptional regulator	-
AOD73_RS00665	152806..153087	-	282	WP_023518248.1	type II toxin-antitoxin system toxin ParE	Toxin
AOD73_RS00670	153084..153311	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
AOD73_RS00675	153487..154107	-	621	WP_003101226.1	hypothetical protein	-
AOD73_RS00680	154208..154708	+	501	WP_003101228.1	LEA type 2 family protein	-
AOD73_RS00685	154781..155122	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
AOD73_RS00690	155204..156631	-	1428	WP_003083784.1	GABA permease	-
AOD73_RS00695	156800..158293	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10472.23 Da
• Isoelectric Point: 10.0435

>T56946 WP_023518248.1 NZ_CP012679:c153087-152806 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRIEITP

Nucleotide

• Length: 282 bp

>T56946 NZ_CP012679:c153087-152806 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATTGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGATCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT56946 WP_003083775.1 NZ_CP012679:c153311-153084 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT56946 NZ_CP012679:c153311-153084 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9