Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 3922782..3923256 Replicon chromosome
Accession NZ_CP012677
Organism Arthrobacter alpinus strain R3.8

Toxin (Protein)


Gene name relE Uniprot ID A0A0M3UH28
Locus tag AOC05_RS17945 Protein ID WP_062008935.1
Coordinates 3922782..3923045 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0M4QQ08
Locus tag AOC05_RS17950 Protein ID WP_062008937.1
Coordinates 3923029..3923256 (-) Length 76 a.a.

Genomic Context

AOC05_RS17955AOC05_RS17940AOC05_RS19125AOC05_RS17945AOC05_RS17950AOC05_RS17960AOC05_RS17965AOC05_RS17970AOC05_RS17975AOC05_RS17980AOC05_RS17985
Location: 3923523..3924704 (1182 bp)
Type: Others
Protein ID: WP_062008940.1
Location: 3919737..3920669 (933 bp)
Type: Others
Protein ID: WP_062008933.1
Location: 3921154..3921858 (705 bp)
Type: Others
Protein ID: WP_082358070.1
Location: 3922782..3923045 (264 bp)
Type: Toxin
Protein ID: WP_062008935.1
Location: 3923029..3923256 (228 bp)
Type: Antitoxin
Protein ID: WP_062008937.1
Location: 3924806..3925372 (567 bp)
Type: Others
Protein ID: WP_062008942.1
Location: 3925376..3925753 (378 bp)
Type: Others
Protein ID: WP_062008943.1
Location: 3925884..3926198 (315 bp)
Type: Others
Protein ID: WP_062008945.1
Location: 3926277..3927479 (1203 bp)
Type: Others
Protein ID: WP_062008947.1
Location: 3927540..3927722 (183 bp)
Type: Others
Protein ID: WP_062008949.1
Location: 3927719..3927970 (252 bp)
Type: Others
Protein ID: WP_062008951.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOC05_RS179403919737..3920669-933WP_062008933.1metallophosphoesterase-
AOC05_RS191253921154..3921858-705WP_082358070.1DUF3761 domain-containing protein-
AOC05_RS179453922782..3923045-264WP_062008935.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AOC05_RS179503923029..3923256-228WP_062008937.1ribbon-helix-helix protein, CopG familyAntitoxin
AOC05_RS179553923523..3924704+1182WP_062008940.1Fic family protein-
AOC05_RS179603924806..3925372-567WP_062008942.1zeta toxin family protein-
AOC05_RS179653925376..3925753-378WP_062008943.1hypothetical protein-
AOC05_RS179703925884..3926198-315WP_062008945.1hypothetical protein-
AOC05_RS179753926277..3927479-1203WP_062008947.1Fic family protein-
AOC05_RS179803927540..3927722-183WP_062008949.1hypothetical protein-
AOC05_RS179853927719..3927970-252WP_062008951.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3911521..395579644275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9801.35 Da        Isoelectric Point: 5.8013

>T56945 WP_062008935.1 NZ_CP012677:c3923045-3922782 [Arthrobacter alpinus]
MAWAVEYDRDALKALKKLDKPVAAKIINYLDDVALLEDPRTQGKALTGNLAGLWRYRIGNYRVICDLIEDQLVIVAVDLG
HRSDIYG

Download         Length: 264 bp

>T56945 NZ_CP012677:c3923045-3922782 [Arthrobacter alpinus]
TTGGCCTGGGCGGTTGAGTATGACCGAGACGCCCTCAAGGCGCTCAAAAAGCTTGATAAACCCGTTGCAGCCAAGATCAT
CAACTACCTCGATGATGTGGCTTTGCTGGAGGACCCCCGCACCCAGGGAAAGGCTCTCACCGGAAACCTTGCTGGTCTGT
GGCGCTACCGGATTGGTAACTACCGAGTAATTTGCGACCTAATTGAGGACCAGCTCGTGATCGTGGCAGTAGATCTGGGC
CACCGTTCCGATATTTACGGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8431.49 Da        Isoelectric Point: 5.8450

>AT56945 WP_062008937.1 NZ_CP012677:c3923256-3923029 [Arthrobacter alpinus]
MPTTVRLPHETEERLDRLAASTGRPKSFYLRELITNGLDKLEWEYSVAQKATDIRAGRRETVSSDDVKVELGLGG

Download         Length: 228 bp

>AT56945 NZ_CP012677:c3923256-3923029 [Arthrobacter alpinus]
ATGCCAACCACCGTTCGACTACCCCATGAAACCGAAGAGCGCCTGGACAGACTGGCGGCCAGCACTGGCCGGCCCAAGTC
GTTCTACTTGCGCGAACTGATCACCAACGGCCTTGACAAGCTGGAGTGGGAATATTCAGTGGCCCAGAAGGCGACTGACA
TTCGTGCTGGTCGCCGCGAGACCGTCTCCAGCGACGACGTGAAGGTTGAACTTGGCCTGGGCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M3UH28

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0M4QQ08

References