Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 3922782..3923256 Replicon chromosome
Accession NZ_CP012677
Organism Arthrobacter alpinus strain R3.8

Toxin (Protein)


Gene name relE Uniprot ID A0A0M3UH28
Locus tag AOC05_RS17945 Protein ID WP_062008935.1
Coordinates 3922782..3923045 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0M4QQ08
Locus tag AOC05_RS17950 Protein ID WP_062008937.1
Coordinates 3923029..3923256 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC05_RS17940 3919737..3920669 - 933 WP_062008933.1 metallophosphoesterase -
AOC05_RS19125 3921154..3921858 - 705 WP_082358070.1 DUF3761 domain-containing protein -
AOC05_RS17945 3922782..3923045 - 264 WP_062008935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOC05_RS17950 3923029..3923256 - 228 WP_062008937.1 ribbon-helix-helix protein, CopG family Antitoxin
AOC05_RS17955 3923523..3924704 + 1182 WP_062008940.1 Fic family protein -
AOC05_RS17960 3924806..3925372 - 567 WP_062008942.1 zeta toxin family protein -
AOC05_RS17965 3925376..3925753 - 378 WP_062008943.1 hypothetical protein -
AOC05_RS17970 3925884..3926198 - 315 WP_062008945.1 hypothetical protein -
AOC05_RS17975 3926277..3927479 - 1203 WP_062008947.1 Fic family protein -
AOC05_RS17980 3927540..3927722 - 183 WP_062008949.1 hypothetical protein -
AOC05_RS17985 3927719..3927970 - 252 WP_062008951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3911521..3955796 44275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9801.35 Da        Isoelectric Point: 5.8013

>T56945 WP_062008935.1 NZ_CP012677:c3923045-3922782 [Arthrobacter alpinus]
MAWAVEYDRDALKALKKLDKPVAAKIINYLDDVALLEDPRTQGKALTGNLAGLWRYRIGNYRVICDLIEDQLVIVAVDLG
HRSDIYG

Download         Length: 264 bp

>T56945 NZ_CP012677:c3923045-3922782 [Arthrobacter alpinus]
TTGGCCTGGGCGGTTGAGTATGACCGAGACGCCCTCAAGGCGCTCAAAAAGCTTGATAAACCCGTTGCAGCCAAGATCAT
CAACTACCTCGATGATGTGGCTTTGCTGGAGGACCCCCGCACCCAGGGAAAGGCTCTCACCGGAAACCTTGCTGGTCTGT
GGCGCTACCGGATTGGTAACTACCGAGTAATTTGCGACCTAATTGAGGACCAGCTCGTGATCGTGGCAGTAGATCTGGGC
CACCGTTCCGATATTTACGGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8431.49 Da        Isoelectric Point: 5.8450

>AT56945 WP_062008937.1 NZ_CP012677:c3923256-3923029 [Arthrobacter alpinus]
MPTTVRLPHETEERLDRLAASTGRPKSFYLRELITNGLDKLEWEYSVAQKATDIRAGRRETVSSDDVKVELGLGG

Download         Length: 228 bp

>AT56945 NZ_CP012677:c3923256-3923029 [Arthrobacter alpinus]
ATGCCAACCACCGTTCGACTACCCCATGAAACCGAAGAGCGCCTGGACAGACTGGCGGCCAGCACTGGCCGGCCCAAGTC
GTTCTACTTGCGCGAACTGATCACCAACGGCCTTGACAAGCTGGAGTGGGAATATTCAGTGGCCCAGAAGGCGACTGACA
TTCGTGCTGGTCGCCGCGAGACCGTCTCCAGCGACGACGTGAAGGTTGAACTTGGCCTGGGCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3UH28

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4QQ08

References