Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3610769..3611570 Replicon chromosome
Accession NZ_CP012675
Organism Proteus mirabilis strain CYPV1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag AOB99_RS16265 Protein ID WP_001094437.1
Coordinates 3610769..3611146 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag AOB99_RS16270 Protein ID WP_001390338.1
Coordinates 3611193..3611570 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOB99_RS18075 3606196..3606512 - 317 Protein_3165 helix-turn-helix transcriptional regulator -
AOB99_RS17450 3607283..3607435 + 153 Protein_3166 transposase -
AOB99_RS16245 3607560..3608594 - 1035 WP_017628609.1 virulence RhuM family protein -
AOB99_RS16250 3609137..3609982 - 846 WP_001274561.1 DUF4942 domain-containing protein -
AOB99_RS16255 3610067..3610264 - 198 WP_000772032.1 DUF957 domain-containing protein -
AOB99_RS17900 3610284..3610772 - 489 WP_000761716.1 hypothetical protein -
AOB99_RS16265 3610769..3611146 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
AOB99_RS16270 3611193..3611570 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOB99_RS16275 3611733..3611954 - 222 WP_000692345.1 DUF987 domain-containing protein -
AOB99_RS16280 3612017..3612493 - 477 WP_001535682.1 RadC family protein -
AOB99_RS17905 3612509..3612982 - 474 WP_000855064.1 antirestriction protein -
AOB99_RS16290 3613324..3614142 - 819 WP_001535681.1 DUF945 domain-containing protein -
AOB99_RS17820 3614297..3614455 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T56943 WP_001094437.1 NZ_CP012675:c3611146-3610769 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T56943 NZ_CP012675:c3611146-3610769 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT56943 WP_001390338.1 NZ_CP012675:c3611570-3611193 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT56943 NZ_CP012675:c3611570-3611193 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References