Detailed information of TA system TA056942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3447488..3448187
• Replicon: chromosome
• Accession: NZ_CP012675
• Organism: Proteus mirabilis strain CYPV1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AOB99_RS15515
• Protein ID: WP_017628658.1
• Coordinates: 3447488..3447874 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AOB99_RS15520
• Protein ID: WP_004246828.1
• Coordinates: 3447867..3448187 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOB99_RS15500	3443507..3444088	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
AOB99_RS15505	3444339..3445244	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AOB99_RS15510	3445254..3447326	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
AOB99_RS15515	3447488..3447874	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOB99_RS15520	3447867..3448187	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AOB99_RS15525	3448236..3448670	-	435	WP_004246827.1	hypothetical protein	-
AOB99_RS15530	3448663..3449547	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
AOB99_RS15535	3449762..3451048	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
AOB99_RS15540	3451185..3451802	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AOB99_RS15545	3452103..3452726	+	624	WP_004246821.1	guanylate kinase	-
AOB99_RS15550	3452781..3453056	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T56942 WP_017628658.1 NZ_CP012675:3447488-3447874 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T56942 NZ_CP012675:3447488-3447874 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT56942 WP_004246828.1 NZ_CP012675:3447867-3448187 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT56942 NZ_CP012675:3447867-3448187 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97