Detailed information of TA system TA056939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1433681..1434326
• Replicon: chromosome
• Accession: NZ_CP012675
• Organism: Proteus mirabilis strain CYPV1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: AOB99_RS06500
• Protein ID: WP_004247035.1
• Coordinates: 1434141..1434326 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: AOB99_RS06495
• Protein ID: WP_004247034.1
• Coordinates: 1433681..1434094 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOB99_RS17955	1429234..1429392	-	159	WP_004247025.1	hypothetical protein	-
AOB99_RS17960	1429844..1430020	+	177	WP_004247793.1	hypothetical protein	-
AOB99_RS06470	1430191..1430937	-	747	WP_017628402.1	methyltransferase domain-containing protein	-
AOB99_RS06480	1431787..1432365	+	579	WP_017628400.1	alpha/beta hydrolase	-
AOB99_RS06485	1432478..1432771	-	294	Protein_1263	LysE family transporter	-
AOB99_RS06490	1433085..1433585	-	501	WP_004247032.1	response regulator	-
AOB99_RS06495	1433681..1434094	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AOB99_RS06500	1434141..1434326	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
AOB99_RS06505	1434437..1435207	+	771	Protein_1267	DUF1073 domain-containing protein	-
AOB99_RS06510	1435766..1436317	-	552	WP_017628396.1	PH domain-containing protein	-
AOB99_RS06515	1436381..1436695	-	315	WP_017628395.1	hypothetical protein	-
AOB99_RS06525	1437102..1438835	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
AOB99_RS06530	1438859..1439086	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1423806..1446308	22502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T56939 WP_004247035.1 NZ_CP012675:c1434326-1434141 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T56939 NZ_CP012675:c1434326-1434141 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT56939 WP_004247034.1 NZ_CP012675:c1434094-1433681 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT56939 NZ_CP012675:c1434094-1433681 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85