Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3608710..3609511 Replicon chromosome
Accession NZ_CP012674
Organism Proteus mirabilis strain CYPM1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag AOC00_RS16240 Protein ID WP_001094437.1
Coordinates 3608710..3609087 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag AOC00_RS16245 Protein ID WP_001390338.1
Coordinates 3609134..3609511 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC00_RS16215 (AOC00_16210) 3604134..3604454 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
AOC00_RS17450 3605224..3605376 + 153 Protein_3214 integrase core domain-containing protein -
AOC00_RS16220 (AOC00_16215) 3605501..3606535 - 1035 WP_017628609.1 RhuM family protein -
AOC00_RS16225 (AOC00_16220) 3607078..3607923 - 846 WP_001274561.1 DUF4942 domain-containing protein -
AOC00_RS16230 (AOC00_16225) 3608008..3608205 - 198 WP_000772032.1 DUF957 domain-containing protein -
AOC00_RS16235 (AOC00_16230) 3608225..3608713 - 489 WP_000761716.1 DUF5983 family protein -
AOC00_RS16240 (AOC00_16235) 3608710..3609087 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
AOC00_RS16245 (AOC00_16240) 3609134..3609511 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOC00_RS16250 (AOC00_16245) 3609674..3609895 - 222 WP_000692345.1 DUF987 domain-containing protein -
AOC00_RS16255 (AOC00_16250) 3609958..3610434 - 477 WP_001535682.1 RadC family protein -
AOC00_RS17675 (AOC00_16255) 3610450..3610923 - 474 WP_000855064.1 antirestriction protein -
AOC00_RS16265 (AOC00_16260) 3611265..3612083 - 819 WP_001535681.1 DUF932 domain-containing protein -
AOC00_RS17845 3612201..3612396 - 196 Protein_3225 DUF905 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T56936 WP_001094437.1 NZ_CP012674:c3609087-3608710 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T56936 NZ_CP012674:c3609087-3608710 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT56936 WP_001390338.1 NZ_CP012674:c3609511-3609134 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT56936 NZ_CP012674:c3609511-3609134 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References