Detailed information of TA system TA056935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3445374..3446073
• Replicon: chromosome
• Accession: NZ_CP012674
• Organism: Proteus mirabilis strain CYPM1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AOC00_RS15495
• Protein ID: WP_017628658.1
• Coordinates: 3445374..3445760 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AOC00_RS15500
• Protein ID: WP_004246828.1
• Coordinates: 3445753..3446073 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOC00_RS15480 (AOC00_15475)	3441393..3441974	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
AOC00_RS15485 (AOC00_15480)	3442225..3443130	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AOC00_RS15490 (AOC00_15485)	3443140..3445212	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
AOC00_RS15495 (AOC00_15490)	3445374..3445760	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOC00_RS15500 (AOC00_15495)	3445753..3446073	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AOC00_RS15505 (AOC00_15500)	3446122..3446556	-	435	WP_004246827.1	hypothetical protein	-
AOC00_RS15510 (AOC00_15505)	3446549..3447433	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
AOC00_RS15515 (AOC00_15510)	3447648..3448934	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
AOC00_RS15520 (AOC00_15515)	3449071..3449688	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AOC00_RS15525 (AOC00_15520)	3449989..3450612	+	624	WP_004246821.1	guanylate kinase	-
AOC00_RS15530 (AOC00_15525)	3450667..3450942	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T56935 WP_017628658.1 NZ_CP012674:3445374-3445760 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T56935 NZ_CP012674:3445374-3445760 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT56935 WP_004246828.1 NZ_CP012674:3445753-3446073 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT56935 NZ_CP012674:3445753-3446073 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97