Detailed information of TA system TA056932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1431519..1432164
• Replicon: chromosome
• Accession: NZ_CP012674
• Organism: Proteus mirabilis strain CYPM1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: AOC00_RS06500
• Protein ID: WP_004247035.1
• Coordinates: 1431979..1432164 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: AOC00_RS06495
• Protein ID: WP_004247034.1
• Coordinates: 1431519..1431932 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOC00_RS17910	1427072..1427230	-	159	WP_004247025.1	hypothetical protein	-
AOC00_RS17915	1427682..1427858	+	177	WP_004247793.1	hypothetical protein	-
AOC00_RS06470 (AOC00_06470)	1428029..1428775	-	747	Protein_1261	methyltransferase domain-containing protein	-
AOC00_RS06480 (AOC00_06480)	1429625..1430203	+	579	WP_017628400.1	alpha/beta hydrolase	-
AOC00_RS06485 (AOC00_06485)	1430316..1430558	-	243	WP_230458803.1	hypothetical protein	-
AOC00_RS06490 (AOC00_06490)	1430923..1431423	-	501	WP_004247032.1	response regulator	-
AOC00_RS06495 (AOC00_06495)	1431519..1431932	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AOC00_RS06500 (AOC00_06500)	1431979..1432164	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
AOC00_RS18090	1432270..1432737	+	468	WP_223293438.1	DUF1073 domain-containing protein	-
AOC00_RS18095	1432680..1433048	+	369	WP_223293455.1	DUF1073 domain-containing protein	-
AOC00_RS18100	1433054..1433275	+	222	Protein_1269	hypothetical protein	-
AOC00_RS06510 (AOC00_06510)	1433604..1434155	-	552	WP_017628396.1	PH domain-containing protein	-
AOC00_RS06515 (AOC00_06515)	1434219..1434533	-	315	WP_017628395.1	hypothetical protein	-
AOC00_RS06525 (AOC00_06525)	1434940..1436673	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
AOC00_RS06530 (AOC00_06530)	1436697..1436924	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1426290..1444145	17855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T56932 WP_004247035.1 NZ_CP012674:c1432164-1431979 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T56932 NZ_CP012674:c1432164-1431979 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT56932 WP_004247034.1 NZ_CP012674:c1431932-1431519 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT56932 NZ_CP012674:c1431932-1431519 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85