Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 19060..19661 Replicon chromosome
Accession NZ_CP012674
Organism Proteus mirabilis strain CYPM1

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag AOC00_RS00090 Protein ID WP_004246497.1
Coordinates 19060..19443 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag AOC00_RS00095 Protein ID WP_004246496.1
Coordinates 19440..19661 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC00_RS00065 (AOC00_00065) 14431..14889 + 459 WP_017628716.1 GNAT family N-acetyltransferase -
AOC00_RS00070 (AOC00_00070) 14985..15722 - 738 WP_004249950.1 tetratricopeptide repeat protein -
AOC00_RS00075 (AOC00_00075) 15831..16730 + 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
AOC00_RS00080 (AOC00_00080) 17087..18325 - 1239 WP_017628714.1 HipA domain-containing protein -
AOC00_RS00085 (AOC00_00085) 18338..18580 - 243 WP_001966699.1 helix-turn-helix transcriptional regulator -
AOC00_RS00090 (AOC00_00090) 19060..19443 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AOC00_RS00095 (AOC00_00095) 19440..19661 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AOC00_RS00100 (AOC00_00100) 19906..20769 - 864 WP_004249947.1 YicC/YloC family endoribonuclease -
AOC00_RS00105 (AOC00_00105) 20896..21612 + 717 WP_004249760.1 ribonuclease PH -
AOC00_RS00110 (AOC00_00110) 21694..22338 + 645 WP_017628713.1 orotate phosphoribosyltransferase -
AOC00_RS00115 (AOC00_00115) 22657..23262 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
AOC00_RS00120 (AOC00_00120) 23382..23840 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T56931 WP_004246497.1 NZ_CP012674:c19443-19060 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T56931 NZ_CP012674:c19443-19060 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT56931 WP_004246496.1 NZ_CP012674:c19661-19440 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT56931 NZ_CP012674:c19661-19440 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References